Discovery of an unexpected iron-sulfur cluster embedded in a human ubiquitin ligase sheds light on how fluctuations in iron and oxygen levels regulate iron homeostasis in human cells through an oxygen-sensitive protein-protein interface.
The American Society for Pharmacology & Experimental Therapeutics has elected our own Dr. William Catterall as Fellow. Congratulations, Bill!
Atomic-level studies of the architecture of tiny sodium channel proteins, critical to generating electrical signals that start off each beat of the heart, are imparting striking details about their function, malfunctions, disruption by many disease mutations, and response to medication. …
Work from the Cirulli and Crisa Labs uncovered a previously unknown function of Connexin 43 as a mediator of stem cell maturation into pancreatic progenitors
Dr. Bill Catterall’s work in the structural mechanisms of ion channels leads to new discoveries about epilepsy…
Nephi Stella, Neuroscience faculty and professor of pharmacology and of psychiatry and behavioral sciences, is one of the 8 who will be officially inducted in September during the annual…
A new crystal structure reveals how a death degron leads to the destruction of proteins…
Dr. Wang was recently appointed as Assistant Dean for Basic Sciences at the University of Washington. Her role is to help improve basic science in medical education within the UW Medical School…
This is a prestigious award named for Nobel laureate Julius Axelrod and highlights Joe’s studies of the cyclic nucleotide phosphodiesterase family of enzymes (PDEs)…