MOLECULAR BASIS
OF DISEASE

Imbalance of Excitation vs. Inhibition in Neural Circuits Is An Important Missing Piece of the Puzzle of Epilepsy and Autism.

The Wang lab studies how mutations in the transcription factor IID complex contributes to cognitive impairment, neurodegeneration, and cancer development.

The Zweifel lab studies synaptic proteins that maintain and refine neural circuit connectivity, and how mutations can lead to neurological disorders.

The Cirulli lab identifies signaling pathways that are activated by cell and matrix interactions in the developing pancreas to target for regeneration.

The Stella lab studies the therapeutic promises of targeting endocannabinoid signaling for the treatment of refractory epilepsies.

The Crisa Lab examines pathways intrinsic to myeloid and vascular cells to boost regeneration and survival of injured pancreatic islet cells.

The Yadav lab is studying the role of autism risk gene TAOK2 in development of dendritic spine and synapses.

The Zheng lab unveils the molecular mechanisms underlying various human disorders using cutting-edge structural biology approaches.

The Scott lab discovers new combinations of clinically approved anticancer drugs that fight adolescent liver cancer.