October 9, 2020
Structural basis of salicylic acid perception by Arabidopsis NPR proteins
Zheng lab reveals how the plant immunity hormone, salicylic acid, which is also the precursor of Aspirin, is perceived by its receptor protein in plants. The results give us a hint on what the same molecule might be able to do in human cells besides targeting the cyclooxygenases.
April 13, 2020
Balancing Cellular Oxygen and Iron Levels.
Discovery of an unexpected iron-sulfur cluster embedded in a human ubiquitin ligase sheds light on how fluctuations in iron and oxygen levels regulate iron homeostasis in human cells through an oxygen-sensitive protein-protein interface.
April 1, 2020
Dr. William Catterall Elected Fellow of ASPET
The American Society for Pharmacology & Experimental Therapeutics has elected our own Dr. William Catterall as Fellow. Congratulations, Bill!
December 19, 2019
Atomic View of the Trigger for the Heartbeat
Atomic-level studies of the architecture of tiny sodium channel proteins, critical to generating electrical signals that start off each beat of the heart, are imparting striking details about their function, malfunctions, disruption by many disease mutations, and response to medication. …
September 27, 2019
Cirulli & Crisa Labs Make the Cover of iScience
Work from the Cirulli and Crisa Labs uncovered a previously unknown function of Connexin 43 as a mediator of stem cell maturation into pancreatic progenitors
September 1, 2019
How the ion channel gears work in the Brain
Dr. Bill Catterall's work in the structural mechanisms of ion channels leads to new discoveries about epilepsy...
August 13, 2019
Nephi Stella elected to the Washington State Academy of Sciences
Nephi Stella, Neuroscience faculty and professor of pharmacology and of psychiatry and behavioral sciences, is one of the 8 who will be officially inducted in September during the annual…
August 8, 2019
Death stalks through ubiquitination
A new crystal structure reveals how a death degron leads to the destruction of proteins...