October 9, 2020

Structural basis of salicylic acid perception by Arabidopsis NPR proteins

Zheng lab reveals how the plant immunity hormone, salicylic acid, which is also the precursor of Aspirin, is perceived by its receptor protein in plants. The results give us a hint on what the same molecule might be able to do in human cells besides targeting the cyclooxygenases.

April 13, 2020

Balancing Cellular Oxygen and Iron Levels.

Discovery of an unexpected iron-sulfur cluster embedded in a human ubiquitin ligase sheds light on how fluctuations in iron and oxygen levels regulate iron homeostasis in human cells through an oxygen-sensitive protein-protein interface.

April 1, 2020

Dr. William Catterall Elected Fellow of ASPET

The American Society for Pharmacology & Experimental Therapeutics has elected our own Dr. William Catterall as Fellow. Congratulations, Bill!

December 19, 2019

Atomic View of the Trigger for the Heartbeat

Atomic-level studies of the architecture of tiny sodium channel proteins, critical to generating electrical signals that start off each beat of the heart, are imparting striking details about their function, malfunctions, disruption by many disease mutations, and response to medication. …

September 27, 2019

Cirulli & Crisa Labs Make the Cover of iScience

Work from the Cirulli and Crisa Labs uncovered a previously unknown function of Connexin 43 as a mediator of stem cell maturation into pancreatic progenitors

September 1, 2019

How the ion channel gears work in the Brain

Dr. Bill Catterall's work in the structural mechanisms of ion channels leads to new discoveries about epilepsy...

August 13, 2019

Nephi Stella elected to the Washington State Academy of Sciences

Nephi Stella, Neuroscience faculty and professor of pharmacology and of psychiatry and behavioral sciences, is one of the 8 who will be officially inducted in September during the annual…

August 8, 2019

Death stalks through ubiquitination

A new crystal structure reveals how a death degron leads to the destruction of proteins...

July 1, 2019

Congratulations Dr. Edith Wang

Dr. Wang was recently appointed as Assistant Dean for Basic Sciences at the University of Washington. Her role is to help improve basic science in medical education within the UW Medical School...