Ptchd1 mediates opioid tolerance via cholesterol-dependent effects on μ-opioid receptor trafficking

The Grill lab in collaboration with Dr. Kirill Martemyanov’s group (UF Scripps Biomedical Labs) has used unbiased forward genetics to identify the Patched family protein PTR-25/Ptchd1 as an ancient, conserved…

Congratulations, Melissa MacEwen!

Melissa has been named one of the Husky 100! We congratulate you on all of your achievements and thank you for the support you have provided the Department of Pharmacology.

Tool Uses Light to Inhibit Neural Activity in Mice

In a study led by Bryan Copits, Ph.D., of the University of Washington School of Medicine, St. Louis, and Michael Bruchas, Ph.D., of the University of Washington, Seattle, researchers developed a tool that can precisely control and inhibit individual neurons.

Charles Chavkin elected as ASPET 2021 Fellow

Selection as a Fellow of the American Society for Pharmacology and Experimental Therapeutics (FASPET) is an honor bestowed to our most distinguished members. Fellows are recognized for their meritorious efforts to advance pharmacology, through their scientific achievements, mentorship, and service to the Society.

UW Pharmacology Virtual Open House Event

The Department of Pharmacology, with the help of the Admissions Committee and Diversity Committee, is hosting a virtual (Zoom) Open House on Wednesday, November 8th!

Vincenzo Cirulli elected to Board of Directors

Vincenzo Cirulli elected to the board of directors of the Diabetes Research Connection 

John D. Scott elected as ASPET 2020 Fellow

Selection as a Fellow of the American Society for Pharmacology and Experimental Therapeutics (FASPET) is an honor bestowed to our most distinguished members. Fellows are recognized for their meritorious efforts to advance pharmacology, through their scientific achievements, mentorship, and service to the Society.

Structural basis of salicylic acid perception by Arabidopsis NPR proteins

Zheng lab reveals how the plant immunity hormone, salicylic acid, which is also the precursor of Aspirin, is perceived by its receptor protein in plants. The results give us a hint on what the same molecule might be able to do in human cells besides targeting the cyclooxygenases.

Balancing Cellular Oxygen and Iron Levels.

Discovery of an unexpected iron-sulfur cluster embedded in a human ubiquitin ligase sheds light on how fluctuations in iron and oxygen levels regulate iron homeostasis in human cells through an oxygen-sensitive protein-protein interface.