Fields of Research
- Neurobiology and Behavior
- Molecular Basis of Disease
- Intracellular Signaling
Research Summary
Elucidating molecular mechanisms that mediate neuronal development and disease.
Research Statement
The Yadav lab is investigating signaling pathways that mediate neuronal development as well as how their dysfunction leads to neurodevelopmental and psychiatric disorders such as autism and schizophrenia. We utilize a combination of powerful approaches in chemical-genetics, induced pluripotent stem cell (iPSC) technology, high-resolution live cell imaging and quantitative proteomics to investigate the role of kinases and their downstream targets in neuronal development and disease.
Awards and Honors
Jaconette Teitze Young Scientist Award 2019
NARSAD Young Investigator Award 2018
NIH Pathway to Independence Award 2015
Smita Yadav
Associate Professor
Affiliations
Institute for Stem Cell and Regenerative Medicine, UW
Center on Human Disease and Disability, UW
UW center for Neurobiology of Addiction, Pain and Emotion
UW Molecular & Cellular Biology Graduate Program
UW Neuroscience Graduate Program
Funding support:
NIH/NIMH
Brain and Behavior Research Foundation
Brotman Baty Institute Collaborative Grant
Research Royalty Fund
Smita Yadav
Associate Professor
Affiliations
Institute for Stem Cell and Regenerative Medicine, UW
Center on Human Disease and Disability, UW
UW center for Neurobiology of Addiction, Pain and Emotion
UW Molecular & Cellular Biology Graduate Program
UW Neuroscience Graduate Program
Funding support:
NIH/NIMH
Brain and Behavior Research Foundation
Brotman Baty Institute Collaborative Grant
Research Royalty Fund
Faculty
- Building:
- Health Sciences Building
- Box:
- 357280
Lab
- Building:
- Health Sciences Building
- Box:
- 357280
Smita Yadav
Associate Professor
Affiliations
Institute for Stem Cell and Regenerative Medicine, UW
Center on Human Disease and Disability, UW
UW center for Neurobiology of Addiction, Pain and Emotion
UW Molecular & Cellular Biology Graduate Program
UW Neuroscience Graduate Program
Funding support:
NIH/NIMH
Brain and Behavior Research Foundation
Brotman Baty Institute Collaborative Grant
Research Royalty Fund
NBIO 404
PHCOL 502/CONJ 532
PHCOL 504
Smita Yadav
Associate Professor
Affiliations
Institute for Stem Cell and Regenerative Medicine, UW
Center on Human Disease and Disability, UW
UW center for Neurobiology of Addiction, Pain and Emotion
UW Molecular & Cellular Biology Graduate Program
UW Neuroscience Graduate Program
Funding support:
NIH/NIMH
Brain and Behavior Research Foundation
Brotman Baty Institute Collaborative Grant
Research Royalty Fund
Sujin Buyan (Neuroscience Graduate Student)
Sarah John (Pharmacology Graduate Student)
Josie Sejd (Pharmacology Graduate Student)
Smita Yadav
Associate Professor
Affiliations
Institute for Stem Cell and Regenerative Medicine, UW
Center on Human Disease and Disability, UW
UW center for Neurobiology of Addiction, Pain and Emotion
UW Molecular & Cellular Biology Graduate Program
UW Neuroscience Graduate Program
Funding support:
NIH/NIMH
Brain and Behavior Research Foundation
Brotman Baty Institute Collaborative Grant
Research Royalty Fund
Select Publications
Beeman N, Sapre T, Ong SE, Yadav S. Neurodevelopmental disorder-associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase. Sci Signal. 2023 Jan 3;16(766):eadd3269. doi: 10.1126/scisignal.add3269. Epub 2023 Jan 3. PubMed PMID: 36595571; PubMed Central PMCID: PMC9970049.
Byeon S, Werner B, Falter R, Davidsen K, Snyder C, Ong SE, Yadav S. Proteomic Identification of Phosphorylation-Dependent Septin 7 Interactors that Drive Dendritic Spine Formation. Front Cell Dev Biol. 2022;10:836746. doi: 10.3389/fcell.2022.836746. eCollection 2022. PubMed PMID: 35602601; PubMed Central PMCID: PMC9114808.
Nourbakhsh K, Ferreccio AA, Bernard MJ, Yadav S. TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules. Dev Cell. 2021 Dec 20;56(24):3321-3333.e5. doi: 10.1016/j.devcel.2021.11.015. Epub 2021 Dec 7. PubMed PMID: 34879262; PubMed Central PMCID: PMC8699727.
Nourbakhsh K, Yadav S. Kinase Signaling in Dendritic Development and Disease. Front Cell Neurosci. 2021;15:624648. doi: 10.3389/fncel.2021.624648. eCollection 2021. Review. PubMed PMID: 33642997; PubMed Central PMCID: PMC7902504.
Yadav S, Oses-Prieto JA, Peters CJ, Zhou J, Pleasure SJ, Burlingame AL, Jan LY, Jan YN. TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine Maturation through Septin7 Phosphorylation. Neuron. 2017 Jan 18;93(2):379-393. doi: 10.1016/j.neuron.2016.12.006. Epub 2017 Jan 5. PubMed PMID: 28065648; PubMed Central PMCID: PMC5267388.
Yadav S, Younger SH, Zhang L, Thompson-Peer KL, Li T, Jan LY, Jan YN. Glial ensheathment of the somatodendritic compartment regulates sensory neuron structure and activity. Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5126-5134. PMID: 30804200
Yadav S, Oses-Prieto JA, Peters CJ, Zhou J, Pleasure SJ, Burlingame AL, Jan LY, Jan YN. TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine Maturation through Septin7 Phosphorylation. Neuron. 2017 Jan 18;93(2):379-393 PubMed PMID: 28065648
Deshpande A, Yadav S, Dao DQ, Wu ZY, Hokanson KC, Cahill MK, Wiita AP, Jan YN, Ullian EM, Weiss LA. Cellular Phenotypes in Human iPSC-Derived Neurons from a Genetic Model of Autism Spectrum Disorder. Cell Rep. 2017 Dec 5;21(10):2678-2687 PubMed PMID: 29212016
Ultanir SK, Yadav S, Hertz NT, Oses-Prieto JA, Claxton S, Burlingame AL, Shokat KM, Jan LY, Jan YN. MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development. Neuron. 2014 Dec 3;84(5):968-82 PubMed PMID: 25456499
Yadav S, Puthenveedu MA, Linstedt AD. Golgin160 recruits the dynein motor to position the Golgi apparatus. Dev Cell. 2012 Jul 17;23(1):153-65 PubMed PMID: 22814606
Publications
Smita Yadav
Associate Professor
Affiliations
Institute for Stem Cell and Regenerative Medicine, UW
Center on Human Disease and Disability, UW
UW center for Neurobiology of Addiction, Pain and Emotion
UW Molecular & Cellular Biology Graduate Program
UW Neuroscience Graduate Program
Funding support:
NIH/NIMH
Brain and Behavior Research Foundation
Brotman Baty Institute Collaborative Grant
Research Royalty Fund