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Contact Information
Courses
Students
Publications
Smita Yadav Profile

Fields of Research

  • Neurobiology and Behavior
  • Molecular Basis of Disease
  • Intracellular Signaling

Research Summary

Elucidating molecular mechanisms that mediate neuronal development and disease.


Research Statement

The Yadav lab is investigating signaling pathways that mediate neuronal development as well as how their dysfunction leads to neurodevelopmental and psychiatric disorders such as autism and schizophrenia. We utilize a combination of powerful approaches in chemical-genetics, induced pluripotent stem cell (iPSC) technology, high-resolution live cell imaging and quantitative proteomics to investigate the role of kinases and their downstream targets in neuronal development and disease.


Awards and Honors

Jaconette Teitze Young Scientist Award 2019

NARSAD Young Investigator Award 2018

NIH Pathway to Independence Award 2015

Smita Yadav

Assistant Professor
3 students

Affiliations

Institute for Stem Cell and Regenerative Medicine, UW

Center on Human Disease and Disability, UW

UW center for Neurobiology of Addiction, Pain and Emotion

UW Molecular & Cellular Biology Graduate Program

UW Neuroscience Graduate Program

Funding support:

NIH/NIMH

Brain and Behavior Research Foundation

Brotman Baty Institute Collaborative Grant

Research Royalty Fund

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Why Pharmacology?

Smita Yadav

Assistant Professor
3 students

Affiliations

Institute for Stem Cell and Regenerative Medicine, UW

Center on Human Disease and Disability, UW

UW center for Neurobiology of Addiction, Pain and Emotion

UW Molecular & Cellular Biology Graduate Program

UW Neuroscience Graduate Program

Funding support:

NIH/NIMH

Brain and Behavior Research Foundation

Brotman Baty Institute Collaborative Grant

Research Royalty Fund

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Contact Information

Faculty

Building:
Health Sciences Building
Room:
J157
Box:
357280
Phone:
206-685-9252
Web Link:
https://yadavlab.com/

Lab

Building:
Health Sciences Building
Room:
J159
Box:
357280
Phone:
206-685-2169
Web Link:
https://yadavlab.com/

Smita Yadav

Assistant Professor
3 students

Affiliations

Institute for Stem Cell and Regenerative Medicine, UW

Center on Human Disease and Disability, UW

UW center for Neurobiology of Addiction, Pain and Emotion

UW Molecular & Cellular Biology Graduate Program

UW Neuroscience Graduate Program

Funding support:

NIH/NIMH

Brain and Behavior Research Foundation

Brotman Baty Institute Collaborative Grant

Research Royalty Fund

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Courses

NBIO404

Smita Yadav

Assistant Professor
3 students

Affiliations

Institute for Stem Cell and Regenerative Medicine, UW

Center on Human Disease and Disability, UW

UW center for Neurobiology of Addiction, Pain and Emotion

UW Molecular & Cellular Biology Graduate Program

UW Neuroscience Graduate Program

Funding support:

NIH/NIMH

Brain and Behavior Research Foundation

Brotman Baty Institute Collaborative Grant

Research Royalty Fund

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Students/Postdocs

Amy Ferreccio (postdoctoral fellow)

Kimya Nourbakhsh (graduate student)

Reilly Falter (research technician)

Smita Yadav

Assistant Professor
3 students

Affiliations

Institute for Stem Cell and Regenerative Medicine, UW

Center on Human Disease and Disability, UW

UW center for Neurobiology of Addiction, Pain and Emotion

UW Molecular & Cellular Biology Graduate Program

UW Neuroscience Graduate Program

Funding support:

NIH/NIMH

Brain and Behavior Research Foundation

Brotman Baty Institute Collaborative Grant

Research Royalty Fund

Explore more on social profiles

Publications

Select Publications

Yadav S, Younger SH, Zhang L, Thompson-Peer KL, Li T, Jan LY, Jan YN. Glial ensheathment of the somatodendritic compartment regulates sensory neuron structure and activity. Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5126-5134. PMID: 30804200

Yadav S, Oses-Prieto JA, Peters CJ, Zhou J, Pleasure SJ, Burlingame AL, Jan LY, Jan YN. TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine Maturation through Septin7 Phosphorylation. Neuron. 2017 Jan 18;93(2):379-393 PubMed PMID: 28065648

Deshpande A, Yadav S, Dao DQ, Wu ZY, Hokanson KC, Cahill MK, Wiita AP, Jan YN, Ullian EM, Weiss LA. Cellular Phenotypes in Human iPSC-Derived Neurons from a Genetic Model of Autism Spectrum Disorder. Cell Rep. 2017 Dec 5;21(10):2678-2687 PubMed PMID: 29212016

Ultanir SK, Yadav S, Hertz NT, Oses-Prieto JA, Claxton S, Burlingame AL, Shokat KM, Jan LY, Jan YN. MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development. Neuron. 2014 Dec 3;84(5):968-82 PubMed PMID: 25456499

Yadav S, Puthenveedu MA, Linstedt AD. Golgin160 recruits the dynein motor to position the Golgi apparatus. Dev Cell. 2012 Jul 17;23(1):153-65 PubMed PMID: 22814606

Publications

Smita Yadav

Assistant Professor
3 students

Affiliations

Institute for Stem Cell and Regenerative Medicine, UW

Center on Human Disease and Disability, UW

UW center for Neurobiology of Addiction, Pain and Emotion

UW Molecular & Cellular Biology Graduate Program

UW Neuroscience Graduate Program

Funding support:

NIH/NIMH

Brain and Behavior Research Foundation

Brotman Baty Institute Collaborative Grant

Research Royalty Fund

Explore more on social profiles