Fields of Research
- Muscarinic Acetylcholine Receptors
- Neuronal Cytokine Receptors
- Signal Transduction in Excitable Cells
Our laboratory has been studying the mechanisms involved in signaling by muscarinic acetylcholine receptors and the cytokines LIF (leukemia inhibitory factor) and CNTF (ciliary neurotrophic factor) in the cardiovascular and nervous systems during both development and normal physiological and disease states.
Our laboratory is interested on how cells in both the heart and the brain communicate. We have been focused on two different systems for signaling. One is comprised of the G-protein coupled muscarinic receptors, which are activated by acetylcholine, one of the main neurotransmitters which controls both the heart and neurons in the peripheral and central nervous systems. We are also focused on the receptors for leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF), which are important for the development and function of both heart and nerve cells. Recent work in the laboratory has identified pathways involved in the initiation of epileptic seizures, new mechanisms for how the function and expression of the receptors which mediate these signals are regulated, and genetic defects in humans which cause profound dysfunction of the autonomic nervous system.
Awards and Honors
Boehringer Ingelheim Research Award
Established Investigator, American Heart Association
FASEB/Wellcome Visiting Professor in the Basic
Medical Sciences Award
Fellow, American Association for the Advancement of Science
MED SCI 510
MED SCI 530
MED SCI 581
Kow, R.L., Cheng, E.M., Jiang, K., Le, J.H., Stella, N., and Nathanson, N.M. (2015) Muscarinic M1 Receptor and Cannabinoid CB1 Receptor Do Not Modulate Paraoxon-Induced Seizures. Pharmacology Research & Perspectives, 3, e00100.
Schmitt, N.S., Rubel, W., and Nathanson, N.M. (2009) Cisplatin-induced hair cell death requires STAT1 and is attenuated by epigallocatechin gallate. J. Neurosci. 29, 3843-3851.
O’Brien, J.J., and Nathanson, N.M. (2007) Retrograde activation of STAT3 by leukemia inhibitory factor in sympathetic neurons. J. Neurochem. 103, 288-302.
Iverson, H.A., Fix, D., Nadler, L.S., Klevit, R.E., and Nathanson, N.M. (2005) Identification and structural analysis of the M3 muscarinic acetylcholine receptor basolateral sorting signal. J. Biol. Chem., 280, 24568–24575.
Hamilton, S.E., and Nathanson, N.M. (2001) The M1 receptor is required for muscarinic activation of MAP kinase in cortical neurons. J. Biol. Chem. 276: 15850- 15853.