Fields of Research
- Drug discovery and precision medicine
- Intracellular signaling
- Molecular basis of disease
Research Summary
Charting the intracellular signaling landscape is the main goal of our studies.
Research Statement
A-kinase Anchoring proteins (AKAPs) constrain protein kinases and phosphatases at defined locations within the cell. AKAP signaling is fundamental to the spatial regulation of physiological processes. Our combination of molecular, genetic and structural approaches have shown that local signaling via AKAPs is key to homeostatic mechanisms that go awry in disease states including cardiovascular diseases, diabetes and cancers.
Awards and Honors
ASPET John J. Abel award in Pharmacology
Oppenheimer Award of the Endocrine Society
Rose Award from the American Society of Biochemistry and Molecular Biology
Ariens prize of the Dutch Pharmacological Society.
Fellow of the Royal Society (London),
Fellow of the Royal Society of Edinburgh
Foreign member of Norwegian Academies of Science and Letters
Serves on scientific advisory boards in the USA, UK, Europe, Australia and Asia.
Dr. John D. Scott
Edwin G. Krebs-Speights Professor of Cell Signaling and Cancer Biology and Chair
Affiliations
UW Molecular & Cellular Biology Graduate Program
UW Neuroscience Graduate Program
Funding support:
NIH/DIDDK
DoD Translational Team Science Award
Fibrolamellar cancer foundation
Dr. John D. Scott
Edwin G. Krebs-Speights Professor of Cell Signaling and Cancer Biology and Chair
Affiliations
UW Molecular & Cellular Biology Graduate Program
UW Neuroscience Graduate Program
Funding support:
NIH/DIDDK
DoD Translational Team Science Award
Fibrolamellar cancer foundation
Faculty
- Building:
- Health Sciences Building K Wing
- Room:
- HSC K336B (Lab); K540 (Chair)
- Box:
- Box 357750
- Phone:
- (206) 616-3340
- Web Link:
- https://johndscottlab.uw.edu/
Lab
- Building:
- Health Sciences Building K Wing
- Room:
- K316, K322, K326
- Box:
- 357750
- Phone:
- (206) 221-0517
- Web Link:
- https://johndscottlab.uw.edu/
Dr. John D. Scott
Edwin G. Krebs-Speights Professor of Cell Signaling and Cancer Biology and Chair
Affiliations
UW Molecular & Cellular Biology Graduate Program
UW Neuroscience Graduate Program
Funding support:
NIH/DIDDK
DoD Translational Team Science Award
Fibrolamellar cancer foundation
CONJ532
Dr. John D. Scott
Edwin G. Krebs-Speights Professor of Cell Signaling and Cancer Biology and Chair
Affiliations
UW Molecular & Cellular Biology Graduate Program
UW Neuroscience Graduate Program
Funding support:
NIH/DIDDK
DoD Translational Team Science Award
Fibrolamellar cancer foundation
Kristan Cleveland (postdoc)
Jerome Falcone (grad student)
Katherine Forbush (Research Scientist IV)
Maryanne Kihiu (grad student)
Sophia Lauer (grad student)
Kyung Lee (Research Scientist II)
Mitchell Omar (postdoc)
Kacey Rosenthal (grad student)
Dr. John D. Scott
Edwin G. Krebs-Speights Professor of Cell Signaling and Cancer Biology and Chair
Affiliations
UW Molecular & Cellular Biology Graduate Program
UW Neuroscience Graduate Program
Funding support:
NIH/DIDDK
DoD Translational Team Science Award
Fibrolamellar cancer foundation
Select Publications
Nygren, P.J., Mehta, S., Schweppe, D.K., Langeberg, L.K., Whiting, J.L., Weisbrod, C.R., Bruce, J.E., Zhang, J., Veesler, D., and Scott, J.D. (2017). Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity. eLife 6.
Smith, F.D., Esseltine, J.L., Nygren, P.J., Veesler, D., Byrne, D.P., Vonderach, M., Strashnov, I., Eyers, C.E., Eyers, P.A., Langeberg, L.K. & Scott,J.D. (2017). Local protein kinase A action proceeds through intact holoenzymes. Science 356, 1288-1293.
Smith, F.D., Omar, M.H., Nygren, P.J., Soughayer, J., Hoshi, N., Lau, H.T., Snyder, C.G., Branon, T.C., Ghosh, D., Langeberg, L.K., & Scott,J.D. (2018). Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins. Proc Natl Acad Sci U S A 115, E11465-E11474.
Turnham, R.E., Smith, F.D., Kenerson, H.L., Omar, M.H., Golkowski, M., Garcia, I., Bauer, R., Lau, H.T., Sullivan, K.M., Langeberg, L.K., Ong S-E, Riehle, K., Yeung, R.,S., & Scott,J.D. (2019). An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling in fibrolamellar carcinoma. eLife 8.
Publications
Dr. John D. Scott
Edwin G. Krebs-Speights Professor of Cell Signaling and Cancer Biology and Chair
Affiliations
UW Molecular & Cellular Biology Graduate Program
UW Neuroscience Graduate Program
Funding support:
NIH/DIDDK
DoD Translational Team Science Award
Fibrolamellar cancer foundation