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A scientist wearing green gloves works with laboratory tools next to an illustration showing a molecular structure related to iron homeostasis, with labeled elements iron (Fe), oxygen (O₂), and a [2Fe2S] cluster.

April 13, 2020

Balancing Cellular Oxygen and Iron Levels.

Discovery of an unexpected iron-sulfur cluster embedded in a human ubiquitin ligase sheds light on how fluctuations in iron and oxygen levels regulate iron homeostasis in human cells through an oxygen-sensitive protein-protein interface.
An older man in academic regalia speaks at an event, with the ASPET logo and the slogan Transforming Discoveries Into Therapies displayed beside him.

April 1, 2020

Dr. William Catterall Elected Fellow of ASPET

The American Society for Pharmacology & Experimental Therapeutics has elected our own Dr. William Catterall as Fellow. Congratulations, Bill!
A split image showing a pufferfish on the left and a molecular illustration of a heart with protein structures and a heart rate graph on the right, suggesting a connection between the fish and heart function.

December 19, 2019

Atomic View of the Trigger for the Heartbeat

Atomic-level studies of the architecture of tiny sodium channel proteins, critical to generating electrical signals that start off each beat of the heart, are imparting striking details about their function, malfunctions, disruption by many disease mutations, and response to medication. …
A man stands at a podium gesturing toward a large display of an iScience journal cover, which features a colorful, microscopic biological image. Windows and trees are visible in the background.

September 27, 2019

Cirulli & Crisa Labs Make the Cover of iScience

Work from the Cirulli and Crisa Labs uncovered a previously unknown function of Connexin 43 as a mediator of stem cell maturation into pancreatic progenitors
Illustration of a human head made of gears, with colorful molecular structures and spiky shapes superimposed, symbolizing the connection between brain function and molecular science.

September 1, 2019

How the ion channel gears work in the Brain

Dr. Bill Catterall's work in the structural mechanisms of ion channels leads to new discoveries about epilepsy...
A group of people sitting together indoors. The man in the foreground is smiling at the camera, while another man beside him points and grins enthusiastically. Others in the background are focused on their work.

August 13, 2019

Nephi Stella elected to the Washington State Academy of Sciences

Nephi Stella, Neuroscience faculty and professor of pharmacology and of psychiatry and behavioral sciences, is one of the 8 who will be officially inducted in September during the annual…
A smiling woman in a black dress stands on a rooftop with city buildings in the background. Next to her is the cover of the Molecular Cell journal, featuring a hooded figure holding a molecular structure.

August 8, 2019

Death stalks through ubiquitination

A new crystal structure reveals how a death degron leads to the destruction of proteins...
A woman wearing gloves uses a pipette, smiling at the camera. Behind her is an illustration of a molecular structure labeled with terms like Winged helix domain, TAF1, TAF7, Triple barrel, and α-helical domain.

July 1, 2019

Congratulations Dr. Edith Wang

Dr. Wang was recently appointed as Assistant Dean for Basic Sciences at the University of Washington. Her role is to help improve basic science in medical education within the UW Medical School...
A man with gray hair and glasses, wearing a maroon shirt, smiles while sitting in a laboratory with various bottles, lab equipment, and culture plates on the bench behind him.

April 12, 2019

Joe Beavo wins ASPET award

This is a prestigious award named for Nobel laureate Julius Axelrod and highlights Joe's studies of the cyclic nucleotide phosphodiesterase family of enzymes (PDEs)...