Fields of Research
- Intracellular signaling
- Molecular basis of disease
Research Summary
Investigating the role of spatial localization which drives aberrant signal transduction in kidney disease.
Research Statement
A kinase anchoring proteins (AKAPs) regulate signaling events by constraining kinases, phosphatases, and their substrates at specific locations in the cell. The dysregulation of such localized signaling drives disease states. I am interested in investigating such states involving the kidneys using both molecular genetics and imaging techniques.
Awards and Honors
Jerome Falcone
Graduate Student
Affiliations
UW Department of Pharmacology
Jerome Falcone
Graduate Student
Affiliations
UW Department of Pharmacology
Faculty
- Building:
- Health Sciences Center K Wing
- Room:
- K326
- Box:
- 357280
- Phone:
- 206-221-0517
- Web Link:
- https://depts.washington.edu/phcol/faculty/scott.php
Lab
- Building:
- Health Sciences Center K Wing
- Room:
- K326
- Box:
- 357280
- Phone:
- 206-221-0517
- Web Link:
- https://depts.washington.edu/phcol/faculty/scott.php
Jerome Falcone
Graduate Student
Affiliations
UW Department of Pharmacology
Jerome Falcone
Graduate Student
Affiliations
UW Department of Pharmacology
Jerome Falcone
Graduate Student
Affiliations
UW Department of Pharmacology
Select Publications
SAR studies on truxillic acid mono esters as a new class of antinociceptive agents targeting fatty acid binding proteins.
Yan S, Elmes MW, Tong S, Hu K, Awwa M, Teng GYH, Jing Y, Freitag M, Gan Q, Clement T, Wei L, Sweeney JM, Joseph OM, Che J, Carbonetti GS, Wang L, Bogdan DM, Falcone J, Smietalo N, Zhou Y, Ralph B, Hsu HC, Li H, Rizzo RC, Deutsch DG, Kaczocha M, Ojima I.
Eur J Med Chem. 2018 Jun 25;154:233-252. doi: 10.1016/j.ejmech.2018.04.050. Epub 2018 May 26.
PMID: 29803996 Free PMC Article
Similar articles
Select item 29440395
Fatty acid-binding protein 5 controls microsomal prostaglandin E synthase 1 (mPGES-1) induction during inflammation.
Bogdan D, Falcone J, Kanjiya MP, Park SH, Carbonetti G, Studholme K, Gomez M, Lu Y, Elmes MW, Smietalo N, Yan S, Ojima I, Puopolo M, Kaczocha M.
J Biol Chem. 2018 Apr 6;293(14):5295-5306. doi: 10.1074/jbc.RA118.001593. Epub 2018 Feb 13.
PMID: 29440395
Publications
Jerome Falcone
Graduate Student
Affiliations
UW Department of Pharmacology