Profile
Contact Information
Courses
Students
Publications
Yasemin Sancak Profile

Fields of Research

  • Intracellular Signaling
  • Molecular Basis of Diseas

Research Summary

Understanding mitochondria and their regulation by calcium signaling.


Research Statement

The Sancak Lab is interested in mitochondria, organelles that play central roles in metabolism, calcium signaling, innate immunity and cell death. Our main focus is understanding how these diverse mitochondrial functions are regulated to answer cellular needs, particularly by calcium signaling. We use cultured cells and animal models to study the function of mitochondrial calcium uptake in these processes.


Awards and Honors

Helen Hay Whitney Foundation Postdoctoral Fellowship Award

Harold M. Weintraub Graduate Student Award

Abraham J. Siegel Fellowship Award

Yasemin Sancak

Assistant Professor
2 students

Affiliations

UW Department of Pharmacology

UW Molecular & Cellular Biology Graduate Program

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Why Pharmacology?

Yasemin Sancak

Assistant Professor
2 students

Affiliations

UW Department of Pharmacology

UW Molecular & Cellular Biology Graduate Program

Explore more on social profiles

Contact Information

Faculty

Building:
Health Sciences Building K Wing
Room:
K-536B
Box:
357280
Phone:
(206)-5430269

Lab

Building:
Health Sciences Building K Wing
Room:
K -526
Phone:
(206)543-8232
Web Link:
https://sites.uw.edu/sancaklb

Yasemin Sancak

Assistant Professor
2 students

Affiliations

UW Department of Pharmacology

UW Molecular & Cellular Biology Graduate Program

Explore more on social profiles

Courses

PHOL514

Yasemin Sancak

Assistant Professor
2 students

Affiliations

UW Department of Pharmacology

UW Molecular & Cellular Biology Graduate Program

Explore more on social profiles

Students/Postdocs

Melissa MacEwen

Tim Locke

Yasemin Sancak

Assistant Professor
2 students

Affiliations

UW Department of Pharmacology

UW Molecular & Cellular Biology Graduate Program

Explore more on social profiles

Publications

Select Publications

Flicker D, Sancak Y, Mick E, Goldberger O, Mootha VK. Exploring the In Vivo Role of the Mitochondrial Calcium Uniporter in Brown Fat Bioenergetics. Cell Rep. 2019 Apr 30;27(5):1364-1375.e5. doi: 10.1016/j.celrep.2019.04.013. PubMed PMID: 31042465.

Kamer KJ, Sancak Y, Fomina Y, Meisel JD, Chaudhuri D, Grabarek Z, Mootha VK. MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca2+ and Mn2+. Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E7960-E7969. doi: 10.1073/pnas.1807811115. Epub 2018 Aug 6. PubMed PMID: 30082385; PubMed Central PMCID: PMC6112746

Kovács-Bogdán E, Sancak Y, Kamer KJ, Plovanich M, Jambhekar A, Huber RJ, Myre MA, Blower MD, Mootha VK.Reconstitution of the mitochondrial calcium uniporter in yeast. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8985-90. doi: 10.1073/pnas.1400514111. Epub 2014 Jun 2. PubMed PMID: 24889638; PubMed Central PMCID: PMC4066498

Sancak Y, Markhard AL, Kitami T, Kovács-Bogdán E, Kamer KJ, Udeshi ND, Carr SA, Chaudhuri D, Clapham DE, Li AA, Calvo SE, Goldberger O, Mootha VK. EMRE is an essential component of the mitochondrial calcium uniporter complex.Science. 2013 Dec 13;342(6164):1379-82. doi: 10.1126/science.1242993. Epub 2013 Nov 14. PubMed PMID: 24231807; PubMed Central PMCID: PMC4091629.

Publications

Yasemin Sancak

Assistant Professor
2 students

Affiliations

UW Department of Pharmacology

UW Molecular & Cellular Biology Graduate Program

Explore more on social profiles