Fields of Research
- Drug Discovery and Precision Medicine
- Intracellular Signaling
- Protein Structure
Research Summary
Precise and quantitative measurements of protein-ligand and protein-protein interactions using a variety of modern biophysical and biochemical methods.
Research Statement
I am a research faculty member working with the Zheng laboratory to train and support junior laboratory members in using biophysical and biochemical techniques to quantify protein-protein and ligand-protein interactions. I develop biochemical and enzymatic assays for determining the activities of the multi-subunit cullin-RING ubiquitin ligases in sensing various cellular signals and ubiquitinating specific substrates, and the deubiquitinating enzymes, called DUBs, in catalyzing the reverse reaction of ubiquitin conjugation. Rigor and reproducibility are the two corner stones of science advancement, which are essential for biomedical research. My expertise lies in the design and implementation of quantitative measurements of biological interactions. I mentor and instruct junior laboratory members on how to perform various types of laboratory procedures so that the experiments are done properly.
Awards and Honors
Thomas Hinds
Research Associate Professor Emeritus
Affiliations
American Society of Biochemistry and molecular Biology
Biophysical society
Red Cell Club
Thomas Hinds
Research Associate Professor Emeritus
Affiliations
American Society of Biochemistry and molecular Biology
Biophysical society
Red Cell Club
Faculty
- Building:
- Health Sciences Building
- Room:
- D418
- Box:
- 357280
- Phone:
- 206-543-0201
Lab
- Building:
- Health Sciences Building
- Room:
- D418
- Box:
- 357280
- Phone:
- 206-543-0201
Thomas Hinds
Research Associate Professor Emeritus
Affiliations
American Society of Biochemistry and molecular Biology
Biophysical society
Red Cell Club
Thomas Hinds
Research Associate Professor Emeritus
Affiliations
American Society of Biochemistry and molecular Biology
Biophysical society
Red Cell Club
Thomas Hinds
Research Associate Professor Emeritus
Affiliations
American Society of Biochemistry and molecular Biology
Biophysical society
Red Cell Club
Select Publications
Recognition of the Diglycine C-End Degron by CRL2KLHDC2 Ubiquitin Ligase.Rusnac DV, Lin HC, Canzani D, Tien KX, Hinds TR, Tsue AF, Bush MF, Yen HS, Zheng N. Mol Cell. 2018 Dec 6;72(5):813-822.
Structural plasticity of D3-D14 ubiquitin ligase in strigolactone signalling.Shabek N, Ticchiarelli F, Mao H, Hinds TR, Leyser O, Zheng N. Nature. 2018 Nov;563(7733):652-656.
Allosteric Activation of Ubiquitin-Specific Proteases by .-Propeller Proteins UAF1 and WDR20.Li H, Lim KS, Kim H, Hinds TR, Jo U, Mao H, Weller CE, Sun J, Chatterjee C, D’Andrea AD, Zheng N.Mol Cell. 2016 Jul 21;63(2):249-260.
Publications
Thomas Hinds
Research Associate Professor Emeritus
Affiliations
American Society of Biochemistry and molecular Biology
Biophysical society
Red Cell Club