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Taran Gujral Profile

Fields of Research

  • Network Pharmacology
  • Wnt Signaling Pathway in Normal and Disease State
  • Developing new experimental and computational strategies for studying signaling within a tissue microenvironment

Research Summary

Dr. Taran Gujral is a systems biologist who takes a big-picture, multidisciplinary approach to studies of cell-cell interactions. He investigates both tumor cells and their microenvironment — the noncancerous cells that surround them. Interactions among the cancerous and noncancerous cells in a tumor influence how well it grows, spreads and resists treatment. Dr. Gujral is looking inside and outside tumor cells to discover the molecular programs initiated by these interactions.


Research Statement

Our lab is focused on understanding the details of how cells respond to external stimuli, both stimuli that are physiological and those that contribute to disease. Cells in multicellular organisms are functionally distinct, and their behavior is influenced by the surrounding cells and tissue, which is referred to as the microenvironment. The molecular networks that let cells respond to stimuli are complex, dynamic, and interconnected. Therefore, studying these networks requires multiple approaches. In addition to using systems biology and computational biology along with cell biology and pharmacology approaches, we are developing new techniques to investigate tissue-specific signaling networks, identify molecular targets for drug discovery, and identify new uses for existing medicines.


Awards and Honors

Sidney Kimmel Scholar Award

American Lung Association Discovery Award

Taran Gujral

3 students

Affiliations

UW Molecular & Cellular Biology Graduate Program

Funding support:

NIH/NCI

DoD

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Why Pharmacology?

Taran Gujral

3 students

Affiliations

UW Molecular & Cellular Biology Graduate Program

Funding support:

NIH/NCI

DoD

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Contact Information

Faculty

Building:
Hutchinson Building
Room:
C3-201
Phone:
206-667-2660
Web Link:
http://research.fhcrc.org/gujral/

Lab

Building:
Hutchinson Building
Room:
C3-201
Phone:
206-667-4149
Web Link:
http://research.fhcrc.org/gujral/

Taran Gujral

3 students

Affiliations

UW Molecular & Cellular Biology Graduate Program

Funding support:

NIH/NCI

DoD

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Courses

PHCOL499

Taran Gujral

3 students

Affiliations

UW Molecular & Cellular Biology Graduate Program

Funding support:

NIH/NCI

DoD

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Students/Postdocs

Nao Nishida-Aoki (Postdoc)

Thomas Bello (Grad student)

Andrew Bondesson(Grad student)

Taran Gujral

3 students

Affiliations

UW Molecular & Cellular Biology Graduate Program

Funding support:

NIH/NCI

DoD

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Publications

Select Publications

Gujral, T.S., Chan, M., Peshkin, L., Sorger, P.K., Kirschner, M.W. and MacBeath, G. A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis. Cell. 159 (4), 844–856 (2014).

Gujral, T.S. and Kirschner M.W. The Hippo pathway mediates resistance to cytotoxic drugs. Proc Natl Acad Sci U S A. 114 (18) E3729-E3738

Gujral, T.S., Peshkin, L., and Kirschner M.W. Exploiting polypharmacology for drug target deconvolution. Proc Natl Acad Sci U S A. 111 (13) 5048-5053 (2014).

Publications

Taran Gujral

3 students

Affiliations

UW Molecular & Cellular Biology Graduate Program

Funding support:

NIH/NCI

DoD

Explore more on social profiles