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Shiyun Cao Profile

Fields of Research

  • Cancer Drug Discovery
  • Structural Biology
  • Ubiquitin Biology

Research Summary

Small molecule regulated oncoprotein ubiquitination and degradation by ubiquitin ligase


Research Statement

I study the molecular mechanism of biological small molecule regulated substrate ubiquitination and degradation by its native E3 ubiquitin ligase. For drug discovery, together with other team members, we aim to discover small molecules for targeted oncoprotein ubiquitination and degradation by selected E3 ubiquitin ligase.


Awards and Honors

Shiyun Cao

Postdoctoral Fellow

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Why Pharmacology?

Shiyun Cao

Postdoctoral Fellow

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Contact Information

Faculty

Building:
Health Sciences Building
Room:
D408

Lab

Building:
Health Sciences Building
Room:
D408
Phone:
206.616.3887
Web Link:
http://depts.washington.edu/zhenglab/

Shiyun Cao

Postdoctoral Fellow

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Courses

Shiyun Cao

Postdoctoral Fellow

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Students/Postdocs

Shiyun Cao

Postdoctoral Fellow

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Publications

Select Publications

Cao, S., Engilberge, S., Girard, E., Gabel, F., Franzetti, B., and Maupin-Furlow, J.A. (2017). Structural insight into ubiquitin-like protein recognition and oligomeric states of JAMM/MPN+ proteases. Structure 25, 823-833.

Cao, S., Hepowit, N., and Maupin-Furlow, J.A. (2015). Ubiquitin-like protein SAMP1 and JAMM/MPN+ metalloprotease HvJAMM1 constitute a system for reversible regulation of metabolic enzyme activity in archaea. PLoS One 10, e0128399.

Publications

Shiyun Cao

Postdoctoral Fellow

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