Fields of Research
- Cancer Drug Discovery
- Structural Biology
- Ubiquitin Biology
Small molecule regulated oncoprotein ubiquitination and degradation by ubiquitin ligase
I study the molecular mechanism of biological small molecule regulated substrate ubiquitination and degradation by its native E3 ubiquitin ligase. For drug discovery, together with other team members, we aim to discover small molecules for targeted oncoprotein ubiquitination and degradation by selected E3 ubiquitin ligase.
Awards and Honors
Cao, S., Engilberge, S., Girard, E., Gabel, F., Franzetti, B., and Maupin-Furlow, J.A. (2017). Structural insight into ubiquitin-like protein recognition and oligomeric states of JAMM/MPN+ proteases. Structure 25, 823-833.
Cao, S., Hepowit, N., and Maupin-Furlow, J.A. (2015). Ubiquitin-like protein SAMP1 and JAMM/MPN+ metalloprotease HvJAMM1 constitute a system for reversible regulation of metabolic enzyme activity in archaea. PLoS One 10, e0128399.