Fields of Research
- Drug Discovery and Precision Medicine
- Intracellular Signaling
- Molecular Basis of Disease
Research Summary
We study cellular states and intracellular signaling with proteogenomics and chemoproteomics approaches
Research Statement
We use system-wide profiling approaches to study signaling networks, regulatory post-translational modification, and cellular processes dysregulated in human disease. Our lab has developed proteomics methods in chemoproteomics and protein quantification, applying these to gain new insights in the epithelial-mesenchymal transition (EMT) in cancer.
Awards and Honors
Ong, S.E. Kinome Analyses in Cancer. UW Science in Medicine New Investigator Award Lecture (Nov 2016).
Shao-En Ong
Associate Professor
Affiliations
Adjunct Associate Professor, UW Genome Sciences
UW Molecular & Cellular Biology Graduate Program
UW Biological Physics, Structure and Design Graduate Program
UW Proteomics Resource
Funding Support:
NIH/NIGMS
DoD
Shao-En Ong
Associate Professor
Affiliations
Adjunct Associate Professor, UW Genome Sciences
UW Molecular & Cellular Biology Graduate Program
UW Biological Physics, Structure and Design Graduate Program
UW Proteomics Resource
Funding Support:
NIH/NIGMS
DoD
Faculty
- Box:
- 357280
- Phone:
- 206-616-6962
- Web Link:
- http://quantbiology.org/
Lab
- Phone:
- 206-685-1882
- Web Link:
- http://quantbiology.org/
Shao-En Ong
Associate Professor
Affiliations
Adjunct Associate Professor, UW Genome Sciences
UW Molecular & Cellular Biology Graduate Program
UW Biological Physics, Structure and Design Graduate Program
UW Proteomics Resource
Funding Support:
NIH/NIGMS
DoD
PHCOL401
PHCOL510
PHCOL513
PHCOL531
CONJ532
BPSD542
Shao-En Ong
Associate Professor
Affiliations
Adjunct Associate Professor, UW Genome Sciences
UW Molecular & Cellular Biology Graduate Program
UW Biological Physics, Structure and Design Graduate Program
UW Proteomics Resource
Funding Support:
NIH/NIGMS
DoD
Golkowski, Martin, Ph.D.
Ho-Tak, Lau, Ph.D.
Myers, Emily
Shoemaker, Anna
Snyder, Calvin
Shao-En Ong
Associate Professor
Affiliations
Adjunct Associate Professor, UW Genome Sciences
UW Molecular & Cellular Biology Graduate Program
UW Biological Physics, Structure and Design Graduate Program
UW Proteomics Resource
Funding Support:
NIH/NIGMS
DoD
Select Publications
Ong, S.E., Blagoev, B., Kratchmarova, I., Kristensen, D.B., Steen, H., Pandey, A., and Mann, M. (2002). Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol Cell Proteomics 1, 376-386.
Ong, S.E., Schenone, M., Margolin, A.A., Li, X., Do, K., Doud, M.K., Mani, D.R., Kuai, L., Wang, X., Wood, J.L., et al. (2009). Identifying the proteins to which small-molecule probes and drugs bind in cells. Proc Natl Acad Sci U S A 106, 4617-4622.
Lau, H.T., Suh, H.W., Golkowski, M., and Ong, S.E. (2014). Comparing SILAC- and stable isotope dimethyl-labeling approaches for quantitative proteomics. J Proteome Res 13, 4164-4174.
Golkowski, M., Vidadala, R.S., Lombard, C.K., Suh, H.W., Maly, D.J., and Ong, S.E. (2017). Kinobead and Single-Shot LC-MS Profiling Identifies Selective PKD Inhibitors. J Proteome Res 16, 1216-1227.
Daniels, C.M., Ong, S.E., and Leung, A.K.L. (2017). ADP-Ribosylated Peptide Enrichment and Site Identification: The Phosphodiesterase-Based Method. Methods Mol Biol 1608, 79-93.
Publications
Shao-En Ong
Associate Professor
Affiliations
Adjunct Associate Professor, UW Genome Sciences
UW Molecular & Cellular Biology Graduate Program
UW Biological Physics, Structure and Design Graduate Program
UW Proteomics Resource
Funding Support:
NIH/NIGMS
DoD