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Contact Information
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Shao-En Ong Profile

Fields of Research

  • Drug Discovery and Precision Medicine
  • Intracellular Signaling
  • Molecular Basis of Disease

Research Summary

We study cellular states and intracellular signaling with proteogenomics and chemoproteomics approaches


Research Statement

We use system-wide profiling approaches to study signaling networks, regulatory post-translational modification, and cellular processes dysregulated in human disease. Our lab has developed proteomics methods in chemoproteomics and protein quantification, applying these to gain new insights in the epithelial-mesenchymal transition (EMT) in cancer.


Awards and Honors

Ong, S.E. Kinome Analyses in Cancer. UW Science in Medicine New Investigator Award Lecture (Nov 2016).

Shao-En Ong

Associate Professor
5 students

Affiliations

Adjunct Associate Professor, UW Genome Sciences

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Why Pharmacology?

Shao-En Ong

Associate Professor
5 students

Affiliations

Adjunct Associate Professor, UW Genome Sciences

Explore more on social profiles

Contact Information

Faculty

Box:
357280
Phone:
206-616-6962
Web Link:
http://quantbiology.org/

Lab

Phone:
206-685-1882
Web Link:
http://quantbiology.org/

Shao-En Ong

Associate Professor
5 students

Affiliations

Adjunct Associate Professor, UW Genome Sciences

Explore more on social profiles

Courses

CONJ532
PHCOL501
PHCOL502
PHCOL506
PHCOL514
PHCOL531

Shao-En Ong

Associate Professor
5 students

Affiliations

Adjunct Associate Professor, UW Genome Sciences

Explore more on social profiles

Students/Postdocs

Shao-En Ong

Associate Professor
5 students

Affiliations

Adjunct Associate Professor, UW Genome Sciences

Explore more on social profiles

Publications

Select Publications

1. Golkowski M, Lius A, Sapre T, Lau HT, Moreno T, Maly DJ, Ong SE. Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity. Mol Cell. 2023 Mar 2;83(5):803-818.e8. PMCID: PMC10072906

2. Golkowski M, Lau H-T, Chan M, Kenerson H, Vidadala VN, Shoemaker A, Maly DJ, Yeung RS, Gujral TS, Ong SE. Pharmacoproteomics Identifies Kinase Pathways that Drive the Epithelial-Mesenchymal Transition and Drug Resistance in Hepatocellular Carcinoma. Cell Syst. 2020 Aug 26;11(2):196-207.e7. PMCID: PMC7484106

3. Ong SE, Blagoev B, Kratchmarova I, Kristensen DB, Steen H, Pandey A, Mann M. Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol Cell Proteomics. 2002 May;1(5):376-86.

4. Blagoev B, Ong SE, Kratchmarova I, Mann M. Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics. Nat Biotechnol. 2004 Sep;22(9):1139-45.

5. Ong SE, Schenone M, Margolin AA, Li X, Do K, Doud MK, Mani DR, Kuai L, Wang X, Wood JL, Tolliday NJ, Koehler AN, Marcaurelle LA, Golub TR, Gould RJ, Schreiber SL, Carr SA. Identifying the proteins to which small-molecule probes and drugs bind in cells. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4617-22. PMCID: PMC2649954.

Publications

Shao-En Ong

Associate Professor
5 students

Affiliations

Adjunct Associate Professor, UW Genome Sciences

Explore more on social profiles