Fields of Research
- Drug Discovery and Precision Medicine
- Intracellular Signaling
- Molecular Basis of Disease
Research Summary
We study cellular states and intracellular signaling with proteogenomics and chemoproteomics approaches
Research Statement
We use system-wide profiling approaches to study signaling networks, regulatory post-translational modification, and cellular processes dysregulated in human disease. Our lab has developed proteomics methods in chemoproteomics and protein quantification, applying these to gain new insights in the epithelial-mesenchymal transition (EMT) in cancer.
Awards and Honors
Ong, S.E. Kinome Analyses in Cancer. UW Science in Medicine New Investigator Award Lecture (Nov 2016).
Shao-En Ong
Associate Professor
Affiliations
Adjunct Associate Professor, UW Genome Sciences
Shao-En Ong
Associate Professor
Affiliations
Adjunct Associate Professor, UW Genome Sciences
Faculty
- Box:
- 357280
- Phone:
- 206-616-6962
- Web Link:
- http://quantbiology.org/
Lab
- Phone:
- 206-685-1882
- Web Link:
- http://quantbiology.org/
Shao-En Ong
Associate Professor
Affiliations
Adjunct Associate Professor, UW Genome Sciences
CONJ532
PHCOL501
PHCOL502
PHCOL506
PHCOL514
PHCOL531
Shao-En Ong
Associate Professor
Affiliations
Adjunct Associate Professor, UW Genome Sciences
Shao-En Ong
Associate Professor
Affiliations
Adjunct Associate Professor, UW Genome Sciences
Select Publications
1. Golkowski M, Lius A, Sapre T, Lau HT, Moreno T, Maly DJ, Ong SE. Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity. Mol Cell. 2023 Mar 2;83(5):803-818.e8. PMCID: PMC10072906
2. Golkowski M, Lau H-T, Chan M, Kenerson H, Vidadala VN, Shoemaker A, Maly DJ, Yeung RS, Gujral TS, Ong SE. Pharmacoproteomics Identifies Kinase Pathways that Drive the Epithelial-Mesenchymal Transition and Drug Resistance in Hepatocellular Carcinoma. Cell Syst. 2020 Aug 26;11(2):196-207.e7. PMCID: PMC7484106
3. Ong SE, Blagoev B, Kratchmarova I, Kristensen DB, Steen H, Pandey A, Mann M. Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol Cell Proteomics. 2002 May;1(5):376-86.
4. Blagoev B, Ong SE, Kratchmarova I, Mann M. Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics. Nat Biotechnol. 2004 Sep;22(9):1139-45.
5. Ong SE, Schenone M, Margolin AA, Li X, Do K, Doud MK, Mani DR, Kuai L, Wang X, Wood JL, Tolliday NJ, Koehler AN, Marcaurelle LA, Golub TR, Gould RJ, Schreiber SL, Carr SA. Identifying the proteins to which small-molecule probes and drugs bind in cells. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4617-22. PMCID: PMC2649954.
Publications
Shao-En Ong
Associate Professor
Affiliations
Adjunct Associate Professor, UW Genome Sciences
