Fields of Research
- Cell and gene therapy
- Intracellular signaling
- Molecular basis of immunological disease
Research Summary
The James lab is interested in uncovering biochemical mechanisms that contribute to drug resistance and to immunological disease.
Research Statement
The following are active interests of the lab:
- Defining the molecular determinants of B cell differentiation into antibody secreting cells
- Mapping the functional effects of genetic variants that contribute to immunological disease (cancer, autoimmunity)
- Determining signaling events that promote resistance to drugs that target B cells and B cell receptor signaling
Awards and Honors
DoD Impact Award
Rich James
Associate Professor
Affiliations
UW Molecular & Cellular Biology Graduate Program
UW M3D Graduate Program
Brotman-Baty Institute
Funding support:
NIH/NCI
NIH/NIAID
Bill & Melinda Gates Foundation
Rich James
Associate Professor
Affiliations
UW Molecular & Cellular Biology Graduate Program
UW M3D Graduate Program
Brotman-Baty Institute
Funding support:
NIH/NCI
NIH/NIAID
Bill & Melinda Gates Foundation
Faculty
- Building:
- Jack Macdonald Building, SCRI
- Room:
- JMB 639
- Box:
- 357280
- Phone:
- 206-884-3290
- Web Link:
- http://www.james-lab.org/
Lab
- Building:
- Jack Macdonald Building, SCRI
- Room:
- 660 (Bays 1-6), 662, 667
- Box:
- 357280
- Web Link:
- http://www.james-lab.org/
Rich James
Associate Professor
Affiliations
UW Molecular & Cellular Biology Graduate Program
UW M3D Graduate Program
Brotman-Baty Institute
Funding support:
NIH/NCI
NIH/NIAID
Bill & Melinda Gates Foundation
Rich James
Associate Professor
Affiliations
UW Molecular & Cellular Biology Graduate Program
UW M3D Graduate Program
Brotman-Baty Institute
Funding support:
NIH/NCI
NIH/NIAID
Bill & Melinda Gates Foundation
Rene Cheng (grad student; MolIE)
Tyler Hill (grad student; MCB)
Alice Chau (fellow)
Nathan Camp (Research Scientist IV)
Tingting Zhang (Research Scientist IV)
Rich James
Associate Professor
Affiliations
UW Molecular & Cellular Biology Graduate Program
UW M3D Graduate Program
Brotman-Baty Institute
Funding support:
NIH/NCI
NIH/NIAID
Bill & Melinda Gates Foundation
Select Publications
Hung KL, Meitlis I, Hale M, Chen CY, Sing S, Jackson SW, Miao CH, Khan IF, Rawlings DJ and James RG. Engineering protein-secreting plasma cells by homology-directed repair in primary human B cells. (2018) Molecular Therapy. 26(2):456-67
Wray-Dutra MN, Al Qureshah F, Metzler G, Oukka M, James RG, Rawlings DJ. Activated PIK3CD drives innate B cell expansion yet limits B cell-intrinsic immune responses. J Exp Med. 2018 Oct 1;215(10):2485-2496.
Wray-Dutra MN, Chawla R, Thomas KR, Seymour BJ, Arkatkar T, Sommer KM, Khim S, Trapnell C, James RG, Rawlings DJ. Activated CARD11 accelerates germinal center kinetics, promoting mTORC1 and terminal differentiation. J Exp Med. 2018 Sep 3;215(9):2445-2461
Tampella G, Kerns HM, Niu D, Singh S, Khim S, Bosch KA, Garrett MG, Moguche A, Evans E, Browning B, Jahan TA, Nacht M, Wolf-Yadlin A, Plebani A, Hamerman JA, Rawlings DJ, James RG. The Tec kinase-regulated phosphoproteome reveals a mechanism for the regulation of inhibitory signals in murine macrophages. (2015) Journal of Immunology 195:246-56.
Publications
Rich James
Associate Professor
Affiliations
UW Molecular & Cellular Biology Graduate Program
UW M3D Graduate Program
Brotman-Baty Institute
Funding support:
NIH/NCI
NIH/NIAID
Bill & Melinda Gates Foundation