Fields of Research
- Drug Discovery and Precision Medicine
- Intracellular Signaling
- Protein Structure
Research Summary
Structural biology of protein ubiquitination, signaling, and therapeutic discovery.
Research Statement
Proteins are architecturally complex macromolecules, which interpret, execute, and maintain the genetic blueprint of life encoded by DNA. Their intricate interactions and coordinated functions are not only critical to all biological processes, but also to every aspect of human health and well-being. We use structural biology approach including cryo-EM and X-ray crystallography to dissect the molecular mechanisms of protein functions and biological interactions in various kingdoms of life. By probing nature in its finest atomic details, we strive to understand what makes life possible and what goes wrong in different human diseases. We aim to applying the underlying principles we learn to the development of novel therapeutics as well as the ecological balance of our planet.
Awards and Honors
Pew Scholar Award
Searle Scholar Award (declined)
Burroughs Welcome Investigator in Pathogenesis of Infectious Diseases
Howard Hughes Medical Institute Investigator
American Association for the Advancement of Science (AAAS) Fellow
Ning Zheng
Professor
Affiliations
Howard Hughes Medical Institute
UW Molecular & Cellular Biology Graduate Program
UW Biological Physics, Structure, & Design Graduate Program
UW Biochemistry Department
UW Molecular Biophysics Training Program
Ning Zheng
Professor
Affiliations
Howard Hughes Medical Institute
UW Molecular & Cellular Biology Graduate Program
UW Biological Physics, Structure, & Design Graduate Program
UW Biochemistry Department
UW Molecular Biophysics Training Program
Faculty
- Building:
- Health Sciences Building
- Room:
- D-409
- Box:
- 357280
- Phone:
- 206-616-3990
- Web Link:
- http://depts.washington.edu/zhenglab/
Lab
- Building:
- Health Sciences Building
- Room:
- D-405, 407, 408, 410, 412, 413, 415, 416, 418
- Box:
- 357280
- Phone:
- 206-616-3887
- Web Link:
- http://depts.washington.edu/zhenglab/
Ning Zheng
Professor
Affiliations
Howard Hughes Medical Institute
UW Molecular & Cellular Biology Graduate Program
UW Biological Physics, Structure, & Design Graduate Program
UW Biochemistry Department
UW Molecular Biophysics Training Program
PhCOL 510
PhCOL 529
PhCOL 550
PhCOL 575
BIOC 530
BPSD 540
MCBD
Ning Zheng
Professor
Affiliations
Howard Hughes Medical Institute
UW Molecular & Cellular Biology Graduate Program
UW Biological Physics, Structure, & Design Graduate Program
UW Biochemistry Department
UW Molecular Biophysics Training Program
Domnita Rusnac (Graduate Student)
Haibin Mao (Research Specialist)
Xiaobo Tang (Research Specialist)
Thomas Hinds (Senior Scientist)
Hui Wang (Research Specialist)
Peter Hsu (Postdoc)
Hui Shi (Postdoc)
Shiyun Cao (Postdoc)
Junping Fan (Postdoc)
Wei Wang (Visiting Associate Professor)
Ning Zheng
Professor
Affiliations
Howard Hughes Medical Institute
UW Molecular & Cellular Biology Graduate Program
UW Biological Physics, Structure, & Design Graduate Program
UW Biochemistry Department
UW Molecular Biophysics Training Program
Select Publications
Shabek N, Ticchiarelli F, Mao H, Hinds TR, Leyser O, Zheng N. 2018. Structural plasticity of D3-D14 Ubiquitin Ligase in Strigolactone Signaling. NATURE 563:652-656.
Hsu PL, Li H, Lau HT, Leonen C, Dhall A, Ong SE, Chatterjee C, Zheng N. 2018. Crystal Structure of the COMPASS H3K4 Methyltransferase Catalytic Module. CELL 174:1106-1116.
Sun J, Bankston JR, Payandeh J, Hinds TR, Zagotta WN, & Zheng N. 2014 Crystal structure of the Plant Dual-affinity Nitrate Transportor NRT1.1. NATURE 701:73-7.
Xing W, Busino L, Hinds TR, Marionni ST, Saifee NH, Bush MF, Pagano M, Zheng N. 2012. SCF-Fbxl3 Ubiquitin Ligase Targets Cryptochromes at Their Cofactor Pocket. NATURE 496: 64-67.
X Tan, LIA Calderon-Villalobos, M Sharon, C Zheng, CV Robinson, M. Estelle, and N Zheng. 2007. Mechanism of Auxin Perception by the TIR1 Ubiquitin Ligase. Nature 446:640-645
Publications
Ning Zheng
Professor
Affiliations
Howard Hughes Medical Institute
UW Molecular & Cellular Biology Graduate Program
UW Biological Physics, Structure, & Design Graduate Program
UW Biochemistry Department
UW Molecular Biophysics Training Program