Fields of Research
Cancer Biology, Cell signaling transduction, Protein Kinase A, A-Kinase anchoring proteins
Research Summary
The oncogenic role of DNAJ-PKAc, the major driver of fibrolamellar carcinoma.
Research Statement
A hallmark genetic alteration in nearly all fibrolamellar carcinoma (FLC) patients is a heterogeneous deletion that produces the pathogenic fusion kinase DNAJ-PKAc. I study the downstream signaling pathways of DNAJ-PKAc, with particular focus on its newly identified interactions with molecular chaperones Hsp70 and BAG2, aiming to uncover novel therapeutic strategies for FLC.
Awards and Honors
Mingu Kang
Postdoctoral Scholar
Affiliations
University of Washington, Department of Pharmacology
Mingu Kang
Postdoctoral Scholar
Affiliations
University of Washington, Department of Pharmacology
Faculty
- Building:
- Health Sciences
- Room:
- K-wing
- Box:
- 357750
Lab
Mingu Kang
Postdoctoral Scholar
Affiliations
University of Washington, Department of Pharmacology
Mingu Kang
Postdoctoral Scholar
Affiliations
University of Washington, Department of Pharmacology
Mingu Kang
Postdoctoral Scholar
Affiliations
University of Washington, Department of Pharmacology
Select Publications
Kang M, Otani Y, Guo Y, Yan J, Goult BT, Howe AK (2024) The focal adhesion protein talin is a mechanically-gated A-kinase anchoring protein (AKAP). Proc Natl Acad Sci U S A. Mar 26;121(13):e2314947121.
Kang M, Senatore AJ, Naughton H, Beltman RJ, Herppich AA, Pflum MKH, Howe AK (2024) Protein Kinase A is a Functional Component of Focal Adhesions. J Biol Chem. May;300(5):107234.
Publications
https://pubmed.ncbi.nlm.nih.gov/25505268/, https://pubmed.ncbi.nlm.nih.gov/26112218/, https://pubmed.ncbi.nlm.nih.gov/27105531/, https://pubmed.ncbi.nlm.nih.gov/28923849/, https://pubmed.ncbi.nlm.nih.gov/38513099/, https://pubmed.ncbi.nlm.nih.gov/38552737/, https://pubmed.ncbi.nlm.nih.gov/40199400/
Mingu Kang
Postdoctoral Scholar
Affiliations
University of Washington, Department of Pharmacology