Fields of Research
- Neuromodulation
- Intracellular Signaling
- In Vivo Pharmacology
- Neural Circuits & Behavior
- Molecular Basis of Neuropsychiatic disease
Research Summary
Neuromodulatory Circuits and GPCR signaling in Affective Behavior
Research Statement
Studies molecular, cellular and system’s level dissection of neuromodulatory circuits in affective behaviors (e.g., reward-aversion, addiction, anxiety-depression, stress, pain). The laboratory uses multidisciplinary approaches including: optogenetic, molecular-biochemical, pharmacological, physiological, in vivo imaging, and computational methods. The lab is actively engaged in bioengineering methods to develop optically-sensitive signaling tools and wireless opto-electronics for detecting-modulating neuronal activity in behaving animals.
Awards and Honors
Jacob P. Waletzsky Memorial Prize 2018, Society for Neuroscience
Mahoney Neuroscience Institute, Rising Star Award 2018, University of Pennsylvania
Henry E. Mallinckrodt Professorship 2017
NIH Brain Initiative Awardee 2016
Young Investigator Award, International Narcotics Research Conference (INRC), 2014
NIH EUREKA Award, 2013
NIH Director’s Transformative R01 Award (TR01), 2012.
Michael Bruchas, PhD
Professor
Affiliations
Center for the Neurobiology of Addiction, Pain and Emotion
Adjunct Professor in the Department of Bioengineering
Graduate Program in Pharmacology
Graduate Program in Neuroscience
Graduate Program in Molecular, Cell Bio (MCB)
Graduate Program in Bioengineering
Funded by NIDA, NIMH, and NINDS
Michael Bruchas, PhD
Professor
Affiliations
Center for the Neurobiology of Addiction, Pain and Emotion
Adjunct Professor in the Department of Bioengineering
Graduate Program in Pharmacology
Graduate Program in Neuroscience
Graduate Program in Molecular, Cell Bio (MCB)
Graduate Program in Bioengineering
Funded by NIDA, NIMH, and NINDS
Faculty
- Building:
- HSB J-wing
- Room:
- 187a
- Box:
- 357360
- Phone:
- 206-543-6870
- Web Link:
- http://www.bruchaslab.org/
Lab
- Building:
- HSB J-Wing
- Room:
- 187a
- Box:
- 357360
- Phone:
- 206-221-7348
- Web Link:
- http://www.bruchaslab.org/
Michael Bruchas, PhD
Professor
Affiliations
Center for the Neurobiology of Addiction, Pain and Emotion
Adjunct Professor in the Department of Bioengineering
Graduate Program in Pharmacology
Graduate Program in Neuroscience
Graduate Program in Molecular, Cell Bio (MCB)
Graduate Program in Bioengineering
Funded by NIDA, NIMH, and NINDS
Neuro 511 Seminar in Advanced Neurobiology, Neural Circuitry Underlying Motivation and Addiction
PChol 534 Molecular Basis of Addiction
Michael Bruchas, PhD
Professor
Affiliations
Center for the Neurobiology of Addiction, Pain and Emotion
Adjunct Professor in the Department of Bioengineering
Graduate Program in Pharmacology
Graduate Program in Neuroscience
Graduate Program in Molecular, Cell Bio (MCB)
Graduate Program in Bioengineering
Funded by NIDA, NIMH, and NINDS
Post-Doctoral and Research Fellows
Daniel Castro, Ph.D
Raaj Gowrishankar Ph.D
Leandra Mangeiri, PhD
Sean Piantadosi, Ph.D
Mitra Hashmeti MD/PhD
Li Li MD, PhD (Stanford)
Graduate Students
Andrew Luskin (Neuro)
Eric Zhang (BioE)
Christian Pedersen (BioE)
Michael Bruchas, PhD
Professor
Affiliations
Center for the Neurobiology of Addiction, Pain and Emotion
Adjunct Professor in the Department of Bioengineering
Graduate Program in Pharmacology
Graduate Program in Neuroscience
Graduate Program in Molecular, Cell Bio (MCB)
Graduate Program in Bioengineering
Funded by NIDA, NIMH, and NINDS
Select Publications
1. K.E. Parker, A.M. Gomez, S.M. Spangler, M. Walicki, S. Feng, R. Al-Hasani,J.G. McCall, B. Copits ,W.J. Planer, T.J. Kash, J. Dougherty, G.D. Stuber, M.R. Bruchas (2019) A Paranigral VTA Prepronociceptin System that Constrains Motivation for Reward. Cell, ul 25;178(3):653-671.e19. doi:10.1016/j.cell.2019.06.034.
2. 1. Qazi R.*, Gomez A.*, Zhou Z., Sim J., Xiong Y., Abdo J., Kim C., Anderson A., Lohner F., Chul Lee B., Jang K., Xiao J., Bruchas M.R.*, Jeong JW.*. (2019) Chronic, Smartphone-enabled Wireless In Vivo Neuropharmacology and Optogenetics., Nature Biomedical Engineering, Aug;3(8):655-669. doi:10.1038/s41551-019-0432-1. *co-corresponding author
3. R Al-Hasani*, J.-M T. Wong*, O. S. Mabrouk, J. G. McCall, G. P. Schmitz, K. A. Porter-Stransky, B. J. Aragona, R. T. Kennedy, M. R. Bruchas (2018) In vivo detection of optically-evoked neuropeptide release. eLife, Sep 3;7. pii: e36520. doi: 10.7554/eLife.36520.
4. L. Xia*, S.K. Nygard*, G.G. Sobczak, N.J. Hourguettes and M.R. Bruchas (2017) Dorsal-CA1 hippocampal neuronal ensembles encode nicotine-reward contextual associations.
Cell Reports, 19(10):2143-2156
5. E.R. Siuda, M. Schmidt, B. Copits, M. Baird., R. Al-Hasani, J. McCall, W. Planer, R. Gereau, M.R.Bruchas. Spatiotemporal control of opioid signaling and behavior. (2015)
Neuron, 86(4):923-35.
6. E. R. Siuda, J.G. McCall, R. Al-Hasani, G. Shin, S. I. Park, M.J. Schmidt, S.L. Anderson, W.J. Planer, J.A. Rogers, and M. R. Bruchas. (2015). Optodynamic simulation of Beta-adrenergic signaling. Nature Communications, Sep 28;6:8480
Michael Bruchas, PhD
Professor
Affiliations
Center for the Neurobiology of Addiction, Pain and Emotion
Adjunct Professor in the Department of Bioengineering
Graduate Program in Pharmacology
Graduate Program in Neuroscience
Graduate Program in Molecular, Cell Bio (MCB)
Graduate Program in Bioengineering
Funded by NIDA, NIMH, and NINDS