Fields of Research
Neurobiology and behavior
Molecular basis of disease
Research Summary
We study the connectivity, physiology, and function of neural circuits that govern motivated behavior.
Research Statement
We are interested in the physiology and circuit connections that underlie the activity patterns and functions of neurons that regulate motivated behavior. We utilize a variety of techniques including patch clamp electrophysiology, gene manipulation with CRISPR/Cas9, fiber photometry, and optogenetics to ask questions about circuit connectivity, gene function, cellular physiology, and behavioral output.
Awards and Honors
Faculty
- Building:
- Health Sciences Building
- Room:
- J-625
- Box:
- Box 357750
- Phone:
- 206-221-3631
- Web Link:
- https://www.sodenlab.org/
Lab
- Building:
- Health Sciences Building
- Room:
- J-631
- Box:
- Box 357750
- Phone:
- 206-221-3631
- Web Link:
- https://www.sodenlab.org/
Select Publications
Soden ME, Chung AS, Cuevas B, Resnick JM, Awatramani R, Zweifel LS. (2020) Anatomic resolution of neurotransmitter-specific projections to the VTA reveals diversity of GABAergic inputs. Nat Neurosci. 23(8):968-980.
Soden ME, Miller SM, Burgeno LM, Phillips PEM, Hnasko TS, Zweifel LS. (2016) Genetic isolation of hypothalamic neurons that regulate context-specific male social behavior. Cell Reports 16(2):304-313.
Soden ME, Jones GL, Sanford CA, Chung AS, Güler AD, Chavkin C, Luján R, Zweifel LS. (2013) Disruption of dopamine neuron activity pattern regulation through selective expression of a human KCNN3 mutation. Neuron 80(4):997-1009.
Publications
