Profile
Contact Information
Courses
Students
Publications
Larry Zweifel Profile

Fields of Research

  • Gene Architecture and Action
  • Molecular Basis of Disease
  • Neurobiology and Behavior

Research Summary

Our research is designed to resolve the genetic regulation of modulatory systems of the brain, such as dopamine, serotonin, and neuropeptides and how these systems regulate motivated behavior.


Research Statement

My research is directed towards resolving the genetic regulation of neural circuit function relating to motivated behavior. We are particularly interested in understanding how genetic mutations implicated in neurodevelopmental and neuropsychiatric disorders alter the function of circuits in the brain. Through the combined use of electrophysiology, neural imaging, neural circuit manipulation, and gene mutagenesis, we investigate the genetic regulation of modulatory neurotransmitter systems of the brain and how altered gene function perturbs basic neural processing and behavior.


Awards and Honors

Larry Zweifel

Associate Professor
7 students

Affiliations

Department of Psychiatry and Behavioral Sciences

Neuroscience Graduate Program

Molecular and Cellular Biology Graduate Program

UW Center for the Neurobiology of Addiction, Pain, and Emotion

UW Center of Excellence in Opioid Addiction Research

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Why Pharmacology?

Larry Zweifel

Associate Professor
7 students

Affiliations

Department of Psychiatry and Behavioral Sciences

Neuroscience Graduate Program

Molecular and Cellular Biology Graduate Program

UW Center for the Neurobiology of Addiction, Pain, and Emotion

UW Center of Excellence in Opioid Addiction Research

Explore more on social profiles

Contact Information

Faculty

Building:
Magnuson Health Sciences Building, J-Wing
Room:
J631F
Box:
357280
Phone:
206-685-6155
Web Link:
https://depts.washington.edu/zweifel/

Lab

Building:
Magnuson Health Sciences Building, J-Wing
Room:
J631
Box:
357370
Phone:
206-616-9813
Web Link:
https://depts.washington.edu/zweifel/

Larry Zweifel

Associate Professor
7 students

Affiliations

Department of Psychiatry and Behavioral Sciences

Neuroscience Graduate Program

Molecular and Cellular Biology Graduate Program

UW Center for the Neurobiology of Addiction, Pain, and Emotion

UW Center of Excellence in Opioid Addiction Research

Explore more on social profiles

Courses

PHCOL 530

PHCOL 534

PHCOL 579

PHCOL 402

Neuro 503

Neuro 527

Larry Zweifel

Associate Professor
7 students

Affiliations

Department of Psychiatry and Behavioral Sciences

Neuroscience Graduate Program

Molecular and Cellular Biology Graduate Program

UW Center for the Neurobiology of Addiction, Pain, and Emotion

UW Center of Excellence in Opioid Addiction Research

Explore more on social profiles

Students/Postdocs

Madison Baird (Phcol Student)

Marcella Cline (MCB Student)

Jordan Elum (Neuro Student)

Avery Hunker (Research Scientist)

Barbara Juarez (Postdoc)

Meagan Quinlan (Postdoc)

Yong Jo (Postdoc)

Larry Zweifel

Associate Professor
7 students

Affiliations

Department of Psychiatry and Behavioral Sciences

Neuroscience Graduate Program

Molecular and Cellular Biology Graduate Program

UW Center for the Neurobiology of Addiction, Pain, and Emotion

UW Center of Excellence in Opioid Addiction Research

Explore more on social profiles

Publications

Select Publications

Soden, M.E., Jones, G.L. Sanford, C.A., Chung, A.S., Guler, A.D. Chavkin, C.C., Luján, R., and Zweifel, L.S. Disruption of Dopamine Neuron Activity Pattern Regulation Through Selective Expression of a Human KCNN3 Mutation. Neuron. 2013 Nov, 80(4):997-1009.

Sanford C.A., Soden M.E., Baird M.A., Miller S.M., Schulkin J., Palmiter R.D., Clark M., Zweifel L.S. A Central Amygdala CRF Circuit Facilitates Learning about Weak Threats. Neuron. 2017 Jan 4;93(1):164-178.

Jo, Y.S., Heymann, G., and Zweifel, L.S. Dopamine neurons reflect the uncertainty in fear generalization. Neuron. 2018 Nov 21;100(4):916-925.

Miller, S.M., Marcotulli, D., Shen, A., and Zweifel, L.S. Divergent medial amygdala projections regulate approach-avoidance conflict behavior. Nat Neurosci. 2019 Apr;22(4):565-575.

Publications

Larry Zweifel

Associate Professor
7 students

Affiliations

Department of Psychiatry and Behavioral Sciences

Neuroscience Graduate Program

Molecular and Cellular Biology Graduate Program

UW Center for the Neurobiology of Addiction, Pain, and Emotion

UW Center of Excellence in Opioid Addiction Research

Explore more on social profiles