Fields of Research
- Drug Discovery and Precision Medicine
Research Summary
Dr. Olson discovers and develops promising new drugs for cancer patients, primarily children with brain cancer.
Research Statement
The Olson Lab identifies, prioritizes, and advances therapeutics into clinical trials for children with brain cancer, with increasing focus on types of brain tumors that are uncommon and have the greatest need for translational research. Our work integrates cutting edge genomics, advanced mouse models of human-derived tumors, functional genomic analyses, and a truly novel approach to advancing effective drug combinations. We intend to increase the cure rate for children with these types of brain cancer by at least 10% from the work done by our team.
Awards and Honors
James Olson
Professor of Pediatrics
Affiliations
Fred Hutchinson Cancer Research Center
Seattle Children’s Hospital
University of Washington
Funding Sources:
NIH/NCI
Washington Research Foundation
Ono Pharmaceutical Co.
Stand Up To Cancer
James Olson
Professor of Pediatrics
Affiliations
Fred Hutchinson Cancer Research Center
Seattle Children’s Hospital
University of Washington
Funding Sources:
NIH/NCI
Washington Research Foundation
Ono Pharmaceutical Co.
Stand Up To Cancer
Faculty
- Building:
- Thomas Building
- Room:
- D4-110
- Box:
- D4-100
- Phone:
- 206-667-7955
- Web Link:
- https://www.fredhutch.org/en/faculty-lab-directory/olson-james.html
Lab
- Building:
- Thomas & Arnold Buildings
- Room:
- D4-275 / M5-C849
- Box:
- D4-100
- Phone:
- 206-667-7955
- Web Link:
- https://research.fhcrc.org/olson/en.html
James Olson
Professor of Pediatrics
Affiliations
Fred Hutchinson Cancer Research Center
Seattle Children’s Hospital
University of Washington
Funding Sources:
NIH/NCI
Washington Research Foundation
Ono Pharmaceutical Co.
Stand Up To Cancer
PHCOL 800 A
PATH 800 A
MCB 600 A
James Olson
Professor of Pediatrics
Affiliations
Fred Hutchinson Cancer Research Center
Seattle Children’s Hospital
University of Washington
Funding Sources:
NIH/NCI
Washington Research Foundation
Ono Pharmaceutical Co.
Stand Up To Cancer
Andrew Mhyre
Chris Mehlin
Colin Correnti
Ashok Bandaranayake
Emily Girard
Mi-Youn Brusniak
Zachary Crook
Jason Price (postdoc)
Jane Carter
Alison Williams (postdoc)
Nicholas Vitanza
Steven Chen
Shelli Morris
Erin Crotty
Shanon Turnbaugh
Midori Clarke
Albe Chan
Matt Biery
Ken Brasel
Gene Hopping
Chunfeng Yin
Andy Strand
Carrie Myers
Simran Handa
Kristina Pilat
Ray Ruff
Morgan Merrill
Ida Lin
Greg Sevilla
Heather Conti
Elizabeth Nguyen
Eric Nealy (grad student)
Eric Ferguson (grad student)
Alyssa Noll (grad student)
James Olson
Professor of Pediatrics
Affiliations
Fred Hutchinson Cancer Research Center
Seattle Children’s Hospital
University of Washington
Funding Sources:
NIH/NCI
Washington Research Foundation
Ono Pharmaceutical Co.
Stand Up To Cancer
Select Publications
Correnti CE, Gewe MM, Mehlin C, Bandaranayake AD, Johnsen, WA, Rupert PB, Brusniak M, Clarke M, Burke SE, de van der Schueren W, Pilat K, Turnbaugh SM, May D, Watson A, Chan MK, Bahl, CD, Olson JM, Strong RK. Multiscale biosynthetic production and global structure-based classification of cystine-dense peptides. Nat Struct Mol Biol 2018
Correnti CE, Laszlo GS, de van der Schueren W, Godwin CD, Bandaranayake AD, Busch MA, Gudgeon CJ, Bates OM, Olson JM, Mehlin C, Walter RB. Simultaneous multiple interaction T-cell engaging (SMITE) bispecific antibodies overcome bispecific T-cell engager (BiTE) resistance via CD28 co-stimulation. Leukemia 2018
Hwang EI, Kool M, Burger PC, Capper D, Chavez L, Brabetz S, Williams-Hughes C, Billups C, Heier L, Jaju A, Michalski J, Li Y, Leary S, Zhou T, von Deimling A, Jones DTW, Fouladi M, Pollack IF, Gajjar A, Packer RJ, Pfister SM, Olson JM. Extensive Molecular and Clinical Heterogeneity in Histologically Diagnosed CNS-PNET Patients Treated as a Single Entity: A Report from the Children’s Oncology Group Randomized ACNS0332 Trial. Jour Clin Onc 2018
Brabetz S, Leary SES, Gröbner SN, Nakamoto MW, Şeker-Cin H, Girard EJ, Cole B, Strand AD, Bloom KL, Hovestadt V, Mack NL, Schwalm B, Korshunov A, Balasubramanian GP, Northcott PA, Pedro K, Dey J, Hansen S, Ditzler S, Lichter P, Chavez L, Jones DTW, Koster J, Pfister SM, Kool M, Olson JM. A biobank of patient-derived pediatric brain tumor models. Nat Med 2018
Publications
James Olson
Professor of Pediatrics
Affiliations
Fred Hutchinson Cancer Research Center
Seattle Children’s Hospital
University of Washington
Funding Sources:
NIH/NCI
Washington Research Foundation
Ono Pharmaceutical Co.
Stand Up To Cancer