Fields of Research
- Drug discovery and precision medicine
- Intracellular signaling
- Molecular basis of disease
Research Summary
Charting the intracellular signaling landscape is the main goal of our studies.
Research Statement
A-kinase Anchoring proteins (AKAPs) constrain protein kinases and phosphatases at defined locations within the cell. AKAP signaling is fundamental to the spatial regulation of physiological processes. Our combination of molecular, genetic and structural approaches have shown that local signaling via AKAPs is key to homeostatic mechanisms that go awry in disease states including cardiovascular diseases, diabetes and cancers.
Awards and Honors
2024 ASPET Julius Axelrod Award in Pharmacology
ASPET John J. Abel award in Pharmacology
Oppenheimer Award of the Endocrine Society
Rose Award from the American Society of Biochemistry and Molecular Biology
Ariens prize of the Dutch Pharmacological Society.
Fellow of the Royal Society (London),
Fellow of the Royal Society of Edinburgh
Foreign member of Norwegian Academies of Science and Letters
Serves on scientific advisory boards in the USA, UK, Europe, Australia and Asia.
Dr. John D. Scott
Edwin G. Krebs-Speights Professor of Cell Signaling and Cancer Biology and Chair
Affiliations
UW Molecular & Cellular Biology Graduate Program
UW Neuroscience Graduate Program
Funding support:
NIH/DIDDK
DoD Translational Team Science Award
Fibrolamellar cancer foundation
Dr. John D. Scott
Edwin G. Krebs-Speights Professor of Cell Signaling and Cancer Biology and Chair
Affiliations
UW Molecular & Cellular Biology Graduate Program
UW Neuroscience Graduate Program
Funding support:
NIH/DIDDK
DoD Translational Team Science Award
Fibrolamellar cancer foundation
Faculty
- Building:
- Health Sciences Building K Wing
- Room:
- HSC K336B (Lab); K357 (Chair)
- Box:
- Box 357750
- Phone:
- (206) 616-3340
- Web Link:
- https://johndscottlab.uw.edu/
Lab
- Building:
- Health Sciences Building K Wing
- Room:
- K316, K322, K326
- Box:
- 357750
- Phone:
- (206) 221-0517
- Web Link:
- https://johndscottlab.uw.edu/
Dr. John D. Scott
Edwin G. Krebs-Speights Professor of Cell Signaling and Cancer Biology and Chair
Affiliations
UW Molecular & Cellular Biology Graduate Program
UW Neuroscience Graduate Program
Funding support:
NIH/DIDDK
DoD Translational Team Science Award
Fibrolamellar cancer foundation
CONJ532
Dr. John D. Scott
Edwin G. Krebs-Speights Professor of Cell Signaling and Cancer Biology and Chair
Affiliations
UW Molecular & Cellular Biology Graduate Program
UW Neuroscience Graduate Program
Funding support:
NIH/DIDDK
DoD Translational Team Science Award
Fibrolamellar cancer foundation
Kristan Cleveland (postdoc)
Jerome Falcone (grad student)
Katherine Forbush (Research Scientist IV)
Mingu Kang (postdoc)
Maryanne Kihiu (grad student)
Kyung Lee (Research Scientist II)
Kacey Rosenthal (grad student)
Dr. John D. Scott
Edwin G. Krebs-Speights Professor of Cell Signaling and Cancer Biology and Chair
Affiliations
UW Molecular & Cellular Biology Graduate Program
UW Neuroscience Graduate Program
Funding support:
NIH/DIDDK
DoD Translational Team Science Award
Fibrolamellar cancer foundation
Select Publications
Omar MH, Byrne DP, Jones KN, Lakey TM, Collins KB, Lee KS, Daly LA, Forbush KA, Lau HT, Golkowski M, McKnight GS, Breault DT, Lefrançois-Martinez AM, Martinez A, Eyers CE, Baird GS, Ong SE, Smith FD, Eyers PA, Scott JD. 2022 Mislocalization of protein kinase A drives pathology in Cushing’s syndrome. Cell Rep. 2022 Jul 12;40(2):111073. PMID: 35830806
Omar MH*, Kihiu M*, Byrne DP, Lee KS, Lakey TM, Butcher E, Eyers PA, Scott JD. (2023) Classification of Cushing’s syndrome PKAc mutants based upon their ability to bind PKI. Biochem J. 2023 Jun 28;480(12):875-890. PMID: 37306403
*co-first author
Lauer SM, Omar MH, Golkowski MG, Kenerson HL, Pascual BC, Forbush K, Smith FD, Gordan J, Ong SE, Yeung RS, Scott JD. (2023) Recruitment of BAG2 to DNAJ-PKAc scaffolds promotes cell survival and resistance to drug-induced apoptosis in fibrolamellar carcinoma. bioRxiv 2023 Jun 28:2023.06.28.546958. Cell Rep. 2024 Feb 27;43(2):113678.
Bock A, Irannejad R, Scott JD. cAMP signaling: a remarkably regional affair. (2024) Trends Biochem Sci. 2024 Feb 2:S0968-0004(24)00018-5. PMID: 38310024
Omar MH, Byrne DP, Shrestha S, Lakey TM, Lee KS, Lauer SM, Collins KB, Daly LA, Eyers CE, Baird GS, Ong SE, Kannan N, Eyers PA, Scott JD. (2024) Discovery of a Cushing’s syndrome protein kinase A mutant that biases signaling through type I AKAPs. Science Advances. 2024 Feb 23;10(8):eadl1258. PMID: 38381834 PMCID: PMC10881042
Publications
Dr. John D. Scott
Edwin G. Krebs-Speights Professor of Cell Signaling and Cancer Biology and Chair
Affiliations
UW Molecular & Cellular Biology Graduate Program
UW Neuroscience Graduate Program
Funding support:
NIH/DIDDK
DoD Translational Team Science Award
Fibrolamellar cancer foundation