Profile
Contact Information
Courses
Students
Publications
David Shechner Profile

Fields of Research

  • Drug Discovery and Precision Medicine
  • Gene Architecture and Action
  • Molecular Basis of Disease

Research Summary

The Shechner lab strives to understand how RNAs regulate mammalian cellular architecture, and to develop novel technologies for probing noncoding RNA functions throughout health and disease.


Research Statement

Beyond coding for proteins, RNA molecules drive an extraordinary array of cellular processes throughout all kingdoms of life. In humans, emerging evidence suggest that many RNAs may play essential and dynamic architectural roles within the cell. This includes RNAs that help to organize higher-order chromatin domains, or which scaffold membraneless organelles that control gene-expression, metabolic, and stress-response programs. Dysregulation of these RNA-mediated structures has been causally implicated in a broad range of human pathologies, including neurodegenerative diseases like ALS, retroviral infections like HIV/AIDS, and nearly all cancers. This implies that RNA-mediated interactions may represent a vast, untapped resource of potential therapeutic targets. Yet, most of these potentially targetable interactions remain uncharacterized, due to the limitations of existing technologies. The Shechner Lab strives to overcome this technological gap, by developing novel methods for interrogating RNAs’ influence on cellular architecture, and for probing the molecular interactions that underlie these architectural functions in both health and disease.


Awards and Honors

CCSG/Safeway Early Career Award in Cancer Research 2019–2020

HHMI/Jane Coffin Childs Memorial Fund Postdoctoral Fellowship 2011–2014

David Shechner

Assistant Professor of Pharmacology
4 students

Affiliations

Graduate Programs:

Pharmacology,

Molecular & Cellular Biology (MCB)

Biological Physics, Structure and Design (BPSD)

Molecular Engineering Sciences (MolES)

Other Affiliations:

UW Center of Nuclear Organization and Function (UW-CNOF)

RNA Society

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Why Pharmacology?

David Shechner

Assistant Professor of Pharmacology
4 students

Affiliations

Graduate Programs:

Pharmacology,

Molecular & Cellular Biology (MCB)

Biological Physics, Structure and Design (BPSD)

Molecular Engineering Sciences (MolES)

Other Affiliations:

UW Center of Nuclear Organization and Function (UW-CNOF)

RNA Society

Explore more on social profiles

Contact Information

Faculty

Building:
Health Sciences Building, K-Wing
Room:
K-335A
Phone:
(206) 543-0776

Lab

Building:
Health Sciences Building, K-Wing
Room:
K-554
Web Link:
http://shechnerlab.org/

David Shechner

Assistant Professor of Pharmacology
4 students

Affiliations

Graduate Programs:

Pharmacology,

Molecular & Cellular Biology (MCB)

Biological Physics, Structure and Design (BPSD)

Molecular Engineering Sciences (MolES)

Other Affiliations:

UW Center of Nuclear Organization and Function (UW-CNOF)

RNA Society

Explore more on social profiles

Courses

PHCOL 514 A (Guest lecturer)

MCB 514 (Guest lecturer)

BIOC 540 A (Guest lecturer)

BPSD 541 (Guest lecturer)

David Shechner

Assistant Professor of Pharmacology
4 students

Affiliations

Graduate Programs:

Pharmacology,

Molecular & Cellular Biology (MCB)

Biological Physics, Structure and Design (BPSD)

Molecular Engineering Sciences (MolES)

Other Affiliations:

UW Center of Nuclear Organization and Function (UW-CNOF)

RNA Society

Explore more on social profiles

Students/Postdocs

Ashley Student (Pharmacology Graduate Student)

Jessica Gianopulos (MCB Graduate Student, joint with Sita Kugel)

Chris Hsu (Technician)

David Shechner

Assistant Professor of Pharmacology
4 students

Affiliations

Graduate Programs:

Pharmacology,

Molecular & Cellular Biology (MCB)

Biological Physics, Structure and Design (BPSD)

Molecular Engineering Sciences (MolES)

Other Affiliations:

UW Center of Nuclear Organization and Function (UW-CNOF)

RNA Society

Explore more on social profiles

Publications

Select Publications

(* co-first authors)

1) P. Maass, R. Barutucu, D.M. Shechner, C.L. Weiner, M. Melé, and J.L. Rinn. Spatiotemporal allele organization by allele-specific CRISPR live-cell imaging (SNP-CLING). Nature Structural and Molecular Biology, 2018, 25(2): 176–84

2) P. Kaewsapsak*, D.M. Shechner*, W. Mallard, J.L. Rinn, and A. Y. Ting. APEX-RIP: Live cell mapping of organelle-associated RNAs by proximity biotinylation and protein-RNA crosslinking. eLife, 2017, 6:e29224

3) D.M. Shechner, E. Hacisuleyman, S.T. Younger, and J.L.Rinn. Multiplexable, locus-specific targeting of long RNAs with CRISPR-Display. Nature Methods, 2015, 12(7): 664–70.

4) D.M. Shechner and D.P. Bartel. The structural basis of RNA-catalyzed RNA polymerization. Nature Structural and Molecular Biology, 2011, 18(9): 1036–42

5) D.M. Shechner, R.A. Grant, S.C. Bagby, Y. Koldobskaya, J.A. Piccirilli, and D.P. Bartel. Crystal structure of the catalytic core of an RNA-polymerase ribozyme. Science, 2009, 326(5957): 1271–5

Publications

David Shechner

Assistant Professor of Pharmacology
4 students

Affiliations

Graduate Programs:

Pharmacology,

Molecular & Cellular Biology (MCB)

Biological Physics, Structure and Design (BPSD)

Molecular Engineering Sciences (MolES)

Other Affiliations:

UW Center of Nuclear Organization and Function (UW-CNOF)

RNA Society

Explore more on social profiles