Profile
Contact Information
Students
Publications
Brock Profile

Fields of Research

  • Cell Signaling
  • Ubiquitin Ligase Biology
  • Genetics of GPCR sensitivity and tolerance
  • Neural Proteomics
  • Neuron Development

Research Summary

Dr. Brock Grill’s overarching interest is understanding how signaling influences development and function of the nervous system. His team’s major research directions include: 1) Using in vivo proteomics to decipher how ubiquitin ligase activity and intracellular signaling hubs affect axon termination, synapse maintenance and neuron function. 2) Using engineered forward genetic approaches to interrogate how u-opioid receptor sensitivity and tolerance are regulated.

Ultimately, Dr. Grill’s lab aims to identify new molecular targets for treating neurodevelopmental disorders, neurodegenerative disease, and opioid addiction/withdrawal.

Research Statement

https://www.seattlechildrens.org/research/centers-programs/integrative-brain-research/our-labs/grill-lab/

 

Awards and Honors

2015 – Cutting Edge Basic Research Award (CEBRA), NIDA

Brock

Principal Investigator - Center for Integrative Brain Research

Affiliations

UW Neuroscience Graduate Program

Seattle Children’s Center for Integrative Brain Research

UW Department of Pediatrics

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Why Pharmacology?

Brock

Principal Investigator - Center for Integrative Brain Research

Affiliations

UW Neuroscience Graduate Program

Seattle Children’s Center for Integrative Brain Research

UW Department of Pediatrics

Explore more on social profiles

Contact Information

Faculty

Phone:
206-884-2972
Web Link:
https://www.seattlechildrens.org/research/centers-programs/integrative-brain-research/our-labs/grill-lab/

Lab

Room:
Seattle Children's Research Institute
Center for Integrative Brain Research
M/S JMB-10
1900 Ninth Ave.
Seattle, WA 98101

Brock

Principal Investigator - Center for Integrative Brain Research

Affiliations

UW Neuroscience Graduate Program

Seattle Children’s Center for Integrative Brain Research

UW Department of Pediatrics

Explore more on social profiles

Courses

Brock

Principal Investigator - Center for Integrative Brain Research

Affiliations

UW Neuroscience Graduate Program

Seattle Children’s Center for Integrative Brain Research

UW Department of Pediatrics

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Students/Postdocs

Nelson Ayala – Graduate Student
Dez Coleman – Graduate Student
Muriel Desbois – Postdoctoral Fellow
Dandan Wang – Postdoctoral Fellow

Brock

Principal Investigator - Center for Integrative Brain Research

Affiliations

UW Neuroscience Graduate Program

Seattle Children’s Center for Integrative Brain Research

UW Department of Pediatrics

Explore more on social profiles

Publications

Select Publications

AlAbdi L, Desbois M… Zheng N, Grill B*, Alkuraya FS*. (2022) Loss-of-function variants in MYCBP2 cause neurobehavioural phenotypes and corpus callosum defects. Brain *co-corresponding authors

Maza N, Wang D, Kowalski C, Stoveken HM, Dao M, Sial OK, Giles AC, Grill B*, Martemyanov KA*. (2022)  Ptchd1 mediates opioid tolerance via cholesterol-dependent effects on μ-opioid receptor trafficking. Nat Neurosci.  *co-corresponding authors

Crawley O, Opperman KJ, Desbois M, Adrados I, Borgen MA, Giles AC, Duckett DR, Grill B (2019) Autophagy is inhibited by ubiquitin ligase activity in the nervous system. Nat Commun Nov 1;10(1):5017. doi: 10.1038/s41467-019-12804-3.

Wang D, Stoveken HM, Zucca S, Dao M, Orlandi C, Song C, Masuho I, Johnston C, Opperman KJ, Giles AC, Gill MS, Lundquist EA, Grill B*, Martemyanov KA*. (2019) Genetic behavioral screen identifies an orphan anti-opioid system. Science. pii: eaau2078. doi: 10.1126/science.aau2078. (abstract) *co-corresponding authors

Giles AC, Desbois M, Opperman KJ, Tavora R, Maroni MJ, Grill B. (2019) A complex containing the O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1regulates GABA neuron function. J Biol Chem. 294, 6843-6856. (abstract)

Borgen MA, Giles AC, Wang D and Grill B. (2019) Synapse maintenance is impacted by ATAT-2 tubulin acetyltransferase activity and the RPM-1 signaling hub. eLife 8, pii: e44040. doi: 10.7554/eLife.44040. (abstract)

Desbois M, Crawley O, Evans PR, Baker ST, Masuho I, Yasuda R, Grill B. (2018) PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2. J Biol Chem. 293, 13897-13909. (abstract)

Crawley O, Giles AC, Desbois M, Kashyap S, Birnbaum RL and Grill B. (2017) A MIG-15/JNK-1 MAP kinase cascade opposes RPM-1 signaling in synapse formation and learning. PLoS Genetics 13(12):e1007095. (abstract)

Borgen MA, Wang D, Grill B. (2017) RPM-1 regulates axon termination by affecting growth cone collapse and microtubule stability. Development 144, 4658-4672.  (abstract)

Publications

https://www.seattlechildrens.org/research/centers-programs/integrative-brain-research/our-labs/grill-lab/publications/

Brock

Principal Investigator - Center for Integrative Brain Research

Affiliations

UW Neuroscience Graduate Program

Seattle Children’s Center for Integrative Brain Research

UW Department of Pediatrics

Explore more on social profiles