Fields of Research
Drug discovery and precision medicine
Intracellular signaling
Molecular basis of disease
Research Summary
Modeling TAOK1-related neurodevelopmental disorders using human stem cell–derived cortical organoids and multi-omic approaches.
Research Statement
My research uses human iPSC-derived dorsal forebrain cortical organoids to model TAOK1-associated neurodevelopmental disorders. By integrating single-cell transcriptomics and proteomics, I study how TAOK1 mutations disrupt cortical development and neural progenitor differentiation, with the goal of identifying pathways that could be targeted for therapeutic intervention.
Awards and Honors
ISCRM Research Fellow (2023)
PSTP Research Trainee (2022)
Edwin G. Krebs Molecular Pharmacology Scholar Award (2021)
Sarah John
Graduate Student
Affiliations
Institute of Stem Cell and Regenerative Medicine
UW Department of Pharmacology Graduate Program
Pharmacological Sciences Training Program
Stanford Brain Organogenesis Program
Sarah John
Graduate Student
Affiliations
Institute of Stem Cell and Regenerative Medicine
UW Department of Pharmacology Graduate Program
Pharmacological Sciences Training Program
Stanford Brain Organogenesis Program
Contact Information
- Building:
- J Wing
- Room:
- J-159
- Box:
- 357750
- Web Link:
- https://yadavlab.com/
Lab
- Building:
- J Wing
- Room:
- J-159
- Box:
- 357750
- Web Link:
- https://yadavlab.com/
Sarah John
Graduate Student
Affiliations
Institute of Stem Cell and Regenerative Medicine
UW Department of Pharmacology Graduate Program
Pharmacological Sciences Training Program
Stanford Brain Organogenesis Program
Sarah John
Graduate Student
Affiliations
Institute of Stem Cell and Regenerative Medicine
UW Department of Pharmacology Graduate Program
Pharmacological Sciences Training Program
Stanford Brain Organogenesis Program
Sarah John
Graduate Student
Affiliations
Institute of Stem Cell and Regenerative Medicine
UW Department of Pharmacology Graduate Program
Pharmacological Sciences Training Program
Stanford Brain Organogenesis Program
Publications
John, S., Rolnick, K., Wilson, L. et al. Bioluminescence for in vivo detection of cell-type-specific inflammation in a mouse model of uveitis. Sci Rep 10, 11377 (2020). https://doi.org/10.1038/s41598-020-68227-4
Aggarwal, S., John, S., Sapra, L. et al. Targeted disruption of PI3K/Akt/mTOR signaling pathway, via PI3K inhibitors, promotes growth inhibitory effects in oral cancer cells. Cancer Chemother Pharmacol 83, 451–461 (2019). https://doi.org/10.1007/s00280-018-3746-x
Sarah John
Graduate Student
Affiliations
Institute of Stem Cell and Regenerative Medicine
UW Department of Pharmacology Graduate Program
Pharmacological Sciences Training Program
Stanford Brain Organogenesis Program