Fields of Research
- Drug Discovery and Precision Medicine
- Molecular Basis of Disease
- Protein Structure
Research Summary
Molecular mechanisms of drug interaction with voltage-gated ion channels.
Research Statement
I’m interested in channelopathy of voltage-gated sodium and calcium ion channels. These are diseases caused by missense mutations of their respective genes. It includes diseases of the nervous system (e.g., epilepsy, familial hemiplegic migraine, episodic ataxia), the muscular system (e.g. hyperkalemic and hypokalemic periodic paralysis), the cardiovascular system (e.g., long QT syndrome, short QT syndrome, Brugada syndrome).
Thousands of diseases have been attributed to ion channels in the last few decades. Thus my second main interest is to improve the affinity and efficacy of classical drugs which are still used to treat these illnesses, and to develop new medications that will target a specific subtype of an ion channel and thus reducing off-target symptoms.
Awards and Honors
Tamer Gamal El-Din
Research Assistant Professor
Affiliations
UW Department of Pharmacology
Tamer Gamal El-Din
Research Assistant Professor
Affiliations
UW Department of Pharmacology
Faculty
- Building:
- Health Sciences Building
- Room:
- F-434
- Box:
- 357280
- Phone:
- 206-685-8792
Lab
- Building:
- Health Sciences Building
- Room:
- F-428
- Box:
- 357280
Tamer Gamal El-Din
Research Assistant Professor
Affiliations
UW Department of Pharmacology
PHCOL 510
PHCOL 529
Tamer Gamal El-Din
Research Assistant Professor
Affiliations
UW Department of Pharmacology
Tamer Gamal El-Din
Research Assistant Professor
Affiliations
UW Department of Pharmacology
Select Publications
Structural Basis for Diltiazem Block of a Voltage-gated Ca2+ Channel
Lin Tang, Tamer M. Gamal El-Din, Michael J. Lenaeus, Ning Zheng, W. A. Catterall.
Molecular Pharmacology 2019, 119.117531; DOI: https://doi.org/10.1124/mol.119.117531
Molecular dissection of slow inactivation in bacterial Sodium Channel NaVAb
Tamer M. Gamal El-Din, Michael J. Lenaeus, Karthik Ramanadane, Ning Zheng, W. A. Catterall.
JGP 2019, Feb 4;151(2):174-185
Fenestrations control the resting state block of a voltage-gated sodium channel.
Tamer M. Gamal El-Din, Michael J. Lenaeus, Ning Zheng, W. A. Catterall.
PNAS. 2018 Dec 18;115(51):13111-13116
Structural basis for gating pore current in periodic paralysis.
Jiang D.*, Tamer M. Gamal El-Din*, Ing C., Lu P., Zheng N., William A. Catterall
Nature. 2018, 505 (7481): 56–61, *First coauthors
Publications
Tamer Gamal El-Din
Research Assistant Professor
Affiliations
UW Department of Pharmacology