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Tamer Gamal El-Din Profile

Fields of Research

  • Drug Discovery and Precision Medicine
  • Molecular Basis of Disease
  • Protein Structure

Research Summary

Molecular mechanisms of drug interaction with voltage-gated ion channels.


Research Statement

I’m interested in channelopathy of voltage-gated sodium and calcium ion channels. These are diseases caused by missense mutations of their respective genes. It includes diseases of the nervous system (e.g., epilepsy, familial hemiplegic migraine, episodic ataxia), the muscular system (e.g. hyperkalemic and hypokalemic periodic paralysis), the cardiovascular system (e.g., long QT syndrome, short QT syndrome, Brugada syndrome).

Thousands of diseases have been attributed to ion channels in the last few decades. Thus my second main interest is to improve the affinity and efficacy of classical drugs which are still used to treat these illnesses, and to develop new medications that will target a specific subtype of an ion channel and thus reducing off-target symptoms.


Awards and Honors

Tamer Gamal El-Din

Research Assistant Professor

Affiliations

UW Department of Pharmacology

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Why Pharmacology?

Tamer Gamal El-Din

Research Assistant Professor

Affiliations

UW Department of Pharmacology

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Contact Information

Faculty

Building:
Health Sciences Building
Room:
F-434
Box:
357280
Phone:
206-685-8792

Lab

Building:
Health Sciences Building
Room:
F-428
Box:
357280

Tamer Gamal El-Din

Research Assistant Professor

Affiliations

UW Department of Pharmacology

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Courses

PHCOL 510

PHCOL 529

Tamer Gamal El-Din

Research Assistant Professor

Affiliations

UW Department of Pharmacology

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Students/Postdocs

Tamer Gamal El-Din

Research Assistant Professor

Affiliations

UW Department of Pharmacology

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Publications

Select Publications

Structural Basis for Diltiazem Block of a Voltage-gated Ca2+ Channel

Lin Tang, Tamer M. Gamal El-Din, Michael J. Lenaeus, Ning Zheng, W. A. Catterall.

Molecular Pharmacology 2019, 119.117531; DOI: https://doi.org/10.1124/mol.119.117531

Molecular dissection of slow inactivation in bacterial Sodium Channel NaVAb

Tamer M. Gamal El-Din, Michael J. Lenaeus, Karthik Ramanadane, Ning Zheng, W. A. Catterall.

JGP 2019, Feb 4;151(2):174-185

Fenestrations control the resting state block of a voltage-gated sodium channel.

Tamer M. Gamal El-Din, Michael J. Lenaeus, Ning Zheng, W. A. Catterall.

PNAS. 2018 Dec 18;115(51):13111-13116

Structural basis for gating pore current in periodic paralysis.

Jiang D.*, Tamer M. Gamal El-Din*, Ing C., Lu P., Zheng N., William A. Catterall

Nature. 2018, 505 (7481): 56–61, *First coauthors

Publications

Tamer Gamal El-Din

Research Assistant Professor

Affiliations

UW Department of Pharmacology

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