Fields of Research
- Drug Discovery and Precision Medicine
- Intracellular Signaling
- Molecular Basis of Disease
Role of voltage-gated ion channels in health and disease.
Voltage-gated sodium and calcium channels are important in the regulation of neurons, glia, cardiac muscle and skeletal muscle. Using genetic, pharmacological, behavioral, and imaging approaches we have elucidated the role of the voltage-gated sodium channel Nav1.1 in Dravet Syndrome and the role and regulation of Cav1.2 cardiac calcium channels in cardiac function. Understanding the role and regulation of ion channels in normal and diseased states is important for the generation of novel therapeutics for devastating disease states including, epilepsy, autism, cardiac hypertrophy and heart failure.
Awards and Honors
Wendel J.C. Krieg Cortical Scholar Award, Cajal, Club
- Heath Sciences Building
- 206 543-1994
- Health Sciences Building
- 206 543-8502
Kaplan J., Stella, N., Catterall W.A., Westenbroek, R.E. (2017) Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndrome. Proc Natl Acad Sci USA. 114(42):11229-11234.
Yang L., Dai D.-F., Yuan C., Westenbroek R.E., West N., de la Iglesia H., Catterall W.A. (2016). Loss of .-adrenergic-stimulated phosphorylation of Cav1.2 channels on Ser1700 leads to heart failure. Proc Natl Acad Sci USA. 113(49):E7976-E7985. Epub 2016 Nov 18.
Rubinstein, M., *Han, S., *Tai, C., Westenbroek, R.E., Hunker, A., Scheuer, T., and Catterall, W.A. (2015) Dissecting the Phenotypes of Dravet Syndrome by Gene Deletion. Brain. 138:2219-2233.
Kalume, F., Oakley, J.C., Westenbroek, R.E., Gile, J., de la Iglesia, H.O., Scheuer, T., Catterall, W.A. (2015). Sleep impairment and reduced interneuron excitability in a mouse model of Dravet syndrome. Neurobiology of Disease 77:141-154.
Westenbroek, R.E., Bischoff, S., Fu, Y., Maier, S.K., Catterall, W.A., Scheuer, T. (2013) Localization of sodium channel subtypes in mouse ventricular myocytes using quantitative immunocytochemistry. J. Mol Cellular Cardiology 64:69-78.