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Richard Gardner Profile

Fields of Research

  • Gene Architecture and Action
  • Intracellular Signaling
  • Molecular Basis of Disease
  • Protein Structure

Research Summary

Regulation of nuclear functions by ubiquitin and ubiquitin-like modifications.


Research Statement

The Gardner lab has a broad scope that focuses on how ubiquitin and ubiquitin-like protein modifiers regulate protein function in the nucleus. Main projects converge on elucidating the mechanisms of ubiquitin-mediated misfolded protein degradation in nuclear protein quality control, understanding the functions of ubiquitination in regulating ribosome biogenesis at the level of ribosomal rDNA transcription and ribosome assembly, and uncovering novel roles of protein sumoylation in response to cellular stress.

We welcome new thoughts and new ideas! Come join us!!


Awards and Honors

Richard Gardner

Professor
4 students

Affiliations

UW Molecular & Cellular Biology Graduate Program

UW Neuroscience Graduate Program

Funding support:

NIH/NIGMS

NSF/MCB

NSF/DGE

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Why Pharmacology?

Richard Gardner

Professor
4 students

Affiliations

UW Molecular & Cellular Biology Graduate Program

UW Neuroscience Graduate Program

Funding support:

NIH/NIGMS

NSF/MCB

NSF/DGE

Explore more on social profiles

Contact Information

Faculty

Building:
Health Sciences Building
Room:
E-421
Box:
357280
Phone:
206-685-0506
Web Link:
https://gardnerlab.org/

Lab

Building:
Health Sciences Building
Room:
E-410
Box:
357280
Phone:
206-616-1976
Web Link:
https://gardnerlab.org/

Richard Gardner

Professor
4 students

Affiliations

UW Molecular & Cellular Biology Graduate Program

UW Neuroscience Graduate Program

Funding support:

NIH/NIGMS

NSF/MCB

NSF/DGE

Explore more on social profiles

Courses

CONJ532

MCB508

MCB514

MCB515

MCB516

PHCOL401

PHCOL512

PHCOL513

PHCOL531

Richard Gardner

Professor
4 students

Affiliations

UW Molecular & Cellular Biology Graduate Program

UW Neuroscience Graduate Program

Funding support:

NIH/NIGMS

NSF/MCB

NSF/DGE

Explore more on social profiles

Students/Postdocs

Heather Borror (Research Scientist I)

Amanda Bradley (grad student)

Timothy Mackie (postdoc)

Nicole Marsh (grad student)

Kevin Thornton (grad student)

Richard Gardner

Professor
4 students

Affiliations

UW Molecular & Cellular Biology Graduate Program

UW Neuroscience Graduate Program

Funding support:

NIH/NIGMS

NSF/MCB

NSF/DGE

Explore more on social profiles

Publications

Select Publications

Oeser, M. L., Amen, T., Nadel, C. M., Bradley, A.I., Reed, B. J., Jones, R. D., Gopalan, J., Kaganovich, D., and R. G. Gardner. 2016. Dynamic sumoylation of a conserved transcription corepressor prevents persistent inclusion formation during hyperosmotic stress. PLoS Genetics 12: e1005809. http://www.ncbi.nlm.nih.gov/pubmed/26800527

Richardson, L. A., Reed, B. J., Charette, M. J., Freed, E. F., Fredrickson, E. K., Locke, M. N., Baserga, S. J., and R. G. Gardner. 2012. A conserved deubiquitinating enzyme controls cell growth by regulating RNA polymerase I stability. Cell Reports 2: 372-385. http://www.ncbi.nlm.nih.gov/pubmed/22902402

Rosenbaum, J. C., Fredrickson, E. K., Oeser, M. L., Garrett-Engele, C. M., Locke, M. N., Richardson, L. A., Nelson, Z. W., Hetrick, E. D., Milac, T. I., Gottschling, D. E., and R. G. Gardner. 2011. Disorder targets misorder in nuclear quality control degradation: an intrinsically disordered ubiquitin ligase directly recognizes misfolded substrates. Molecular Cell 41: 93-106. http://www.ncbi.nlm.nih.gov/pubmed/21211726

Gardner, R. G., Nelson, Z. W., and D. E. Gottschling. 2005. Degradation-mediated protein quality control in the nucleus. Cell 120: 803-815. http://www.ncbi.nlm.nih.gov/pubmed/15797381

Gardner, R. G., Nelson, Z. W., and D. E. Gottschling. 2005. Ubp10/Dot4p regulates the persistence of ubiquitinated histone H2B: distinct roles in telomeric silencing and general chromatin. Molecular and Cellular Biology 25: 6123-6139. http://www.ncbi.nlm.nih.gov/pubmed/15988024

Publications

Richard Gardner

Professor
4 students

Affiliations

UW Molecular & Cellular Biology Graduate Program

UW Neuroscience Graduate Program

Funding support:

NIH/NIGMS

NSF/MCB

NSF/DGE

Explore more on social profiles