Fields of Research
- Kinase Biochemistry
- Molecular Basis of Disease
Elucidating the role of autism susceptibility gene, TAOK2, in neuronal growth and development.
TAOK2 is an autism risk gene that encodes a serine threonine kinase important for neuronal development. Using innovative strategies including genome editing, stem cell technology and proteomic approaches, we aim to elucidate the role of TAOK2 in early human neurodevelopment as well as determine how aberrant TAOK2 signaling contributes to neuropathology associated with autism and schizophrenia.
Awards and Honors
PSTP Fellow 2019-
P Barros E, Malmstrom RD, Nourbakhsh K, Del Rio JC, Kornev AP, Taylor SS, Amaro RE. Electrostatic Interactions as Mediators in the Allosteric Activation of Protein Kinase A RIα. Biochemistry. 2017 Mar 14;56(10):1536-1545. doi: 10.1021/acs.biochem.6b01152. Epub 2017 Mar 6. PubMed PMID: 28221775; PubMed Central PMCID: PMC5495472.