Fields of Research
- Drug Discovery and Precision Medicine
- Molecular Basis of Disease
- Protein Structure
Research Summary
I am using crystallography and cryo-EM to study membrane proteins that involved in important pathways.
Research Statement
Membrane proteins carry very important functions in all the organisms, from bacteria to human. I am interested in membrane E3 ligases in ubiquitin dependent proteolysis, which is responsible for the degradation of misfolding proteins. Many human disorders, including neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease, diabetes, cystic fibrosis and certain cancers, are associated with abnormalities. I am using crystallography and cryo-EM to study the membrane E3 ligases, try to answer questions like how are they functioning, what is the mechanism of subsubstrate recognition and retro location. Then we can get better understanding of these drug targets for treating diseases mentioned above.
Awards and Honors
Junping Fan
Postdoctoral Fellow
Affiliations
UW Department of Pharmacology
Howard Hughes Medical Institute
Junping Fan
Postdoctoral Fellow
Affiliations
UW Department of Pharmacology
Howard Hughes Medical Institute
Faculty
- Building:
- Health Science Building
- Room:
- D408
- Box:
- 357280
- Phone:
- 206-616-3887
Lab
- Building:
- Health Science Building
- Room:
- D408
- Box:
- 357280
- Phone:
- 206-616-3887
Junping Fan
Postdoctoral Fellow
Affiliations
UW Department of Pharmacology
Howard Hughes Medical Institute
Junping Fan
Postdoctoral Fellow
Affiliations
UW Department of Pharmacology
Howard Hughes Medical Institute
Junping Fan
Postdoctoral Fellow
Affiliations
UW Department of Pharmacology
Howard Hughes Medical Institute
Select Publications
Fan, J.; Jiang, D. H.; Zhao, Y.; Liu, J. F.; Zhang, X. J. C., P Natl Acad Sci USA 2014. 111(21): p. 7636-40.
Jiang, D. H. *; Fan, J. *; Wang, X. P.; Zhao, Y.; Huang, B.; Liu, J. F.; Zhang, X. J. C., Journal of structural biology 2012, 180 (3), 447-457. (*co-first author)
Kamischke, C., Fan, J., Bergeron, J., Kulasekara, H.D., Dalebroux, Z.D., Burrell, A., Kollman, J.M., and Miller, S.I. (2019). . eLife 8
Publications
Junping Fan
Postdoctoral Fellow
Affiliations
UW Department of Pharmacology
Howard Hughes Medical Institute