Profile
Contact Information
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Junping Fan Profile

Fields of Research

  • Drug Discovery and Precision Medicine
  • Molecular Basis of Disease
  • Protein Structure

Research Summary

I am using crystallography and cryo-EM to study membrane proteins that involved in important pathways.


Research Statement

Membrane proteins carry very important functions in all the organisms, from bacteria to human. I am interested in membrane E3 ligases in ubiquitin dependent proteolysis, which is responsible for the degradation of misfolding proteins. Many human disorders, including neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease, diabetes, cystic fibrosis and certain cancers, are associated with abnormalities. I am using crystallography and cryo-EM to study the membrane E3 ligases, try to answer questions like how are they functioning, what is the mechanism of subsubstrate recognition and retro location. Then we can get better understanding of these drug targets for treating diseases mentioned above.


Awards and Honors

Junping Fan

Postdoctoral Fellow

Affiliations

UW Department of Pharmacology

Howard Hughes Medical Institute

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Why Pharmacology?

Junping Fan

Postdoctoral Fellow

Affiliations

UW Department of Pharmacology

Howard Hughes Medical Institute

Explore more on social profiles

Contact Information

Faculty

Building:
Health Science Building
Room:
D408
Box:
357280
Phone:
206-616-3887

Lab

Building:
Health Science Building
Room:
D408
Box:
357280
Phone:
206-616-3887

Junping Fan

Postdoctoral Fellow

Affiliations

UW Department of Pharmacology

Howard Hughes Medical Institute

Explore more on social profiles

Courses

Junping Fan

Postdoctoral Fellow

Affiliations

UW Department of Pharmacology

Howard Hughes Medical Institute

Explore more on social profiles

Students/Postdocs

Junping Fan

Postdoctoral Fellow

Affiliations

UW Department of Pharmacology

Howard Hughes Medical Institute

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Publications

Select Publications

Fan, J.; Jiang, D. H.; Zhao, Y.; Liu, J. F.; Zhang, X. J. C., P Natl Acad Sci USA 2014. 111(21): p. 7636-40.

Jiang, D. H. *; Fan, J. *; Wang, X. P.; Zhao, Y.; Huang, B.; Liu, J. F.; Zhang, X. J. C., Journal of structural biology 2012, 180 (3), 447-457. (*co-first author)

Kamischke, C., Fan, J., Bergeron, J., Kulasekara, H.D., Dalebroux, Z.D., Burrell, A., Kollman, J.M., and Miller, S.I. (2019). . eLife 8

Publications

Junping Fan

Postdoctoral Fellow

Affiliations

UW Department of Pharmacology

Howard Hughes Medical Institute

Explore more on social profiles