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Contact Information
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Harrison Fontaine Profile

Fields of Research

  • Drug Discovery and Precision Medicine
  • Molecular Basis of Psychiatric Disease
  • Neurobiology and Behavior

Research Summary

The Chavkin Lab studies the molecular and behvioaral pharmacology of endogenous peptide transmitters in the context of stress, pain, addiction, and depression.


Research Statement

I utilize genetic, pharmacological, and optogenetic techniques to dissect specific mechanisms mediating stress sensitization to reward and aversion. More specifically, I interrogate how acute stress-induced activation of kappa opioid receptors (KOR) increases preference for drug and social interaction via modulation of serotonin tone and postsynaptic serotonin receptors within the brain’s reward circuitry. Additionally, I study how chronic stress-induced activation of KOR leads to depression-like behavior by sensitization to the aversive properties of stressors.


Awards and Honors

Harrison Fontaine

Graduate Student

Affiliations

UW Department of Pharmacology

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Why Pharmacology?

Harrison Fontaine

Graduate Student

Affiliations

UW Department of Pharmacology

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Contact Information

Faculty

Building:
HSBJ
Room:
J681A
Box:
357750

Lab

Building:
HSBJ
Room:
J681
Box:
357750
Phone:
(206) 543-1127
Web Link:
http://depts.washington.edu/uwconte/chavkinlab/

Harrison Fontaine

Graduate Student

Affiliations

UW Department of Pharmacology

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Courses

Harrison Fontaine

Graduate Student

Affiliations

UW Department of Pharmacology

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Students/Postdocs

Harrison Fontaine

Graduate Student

Affiliations

UW Department of Pharmacology

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Publications

Select Publications

Abraham, A. D., Fontaine, H. M., Song, A. J., Andrews, M. M., Baird, M. A., Kieffer, B. L., … & Chavkin, C. (2018). .-opioid receptor activation in dopamine neurons disrupts behavioral inhibition. Neuropsychopharmacology, 43(2), 362.

Abraham, A. D., Schattauer, S. S., Reichard, K. L., Cohen, J. H., Fontaine, H. M., Song, A. J., … & Chavkin, C. (2018). Estrogen regulation of GRK2 inactivates kappa opioid receptor signaling mediating analgesia, but not aversion. Journal of Neuroscience, 38(37), 8031-8043.

Publications

Harrison Fontaine

Graduate Student

Affiliations

UW Department of Pharmacology

Explore more on social profiles