Fields of Research
- G protein-coupled receptors
- Cell biology
- Assay Development
The goal of our research is to understand the molecular mechanisms of drug action at G protein-coupled receptors (GPCRs). We are currently focused on deciphering how GPCRs are organized as macromolecular protein complexes in cell membranes. We recently revealed the alpha1D-adrenergic receptor, a key regulator of cardiovascular, nervous system, and urinary function, associates with the multiple PDZ-domain containing proteins in human cells, and that these interactions are unique amongst human GPCRs containing Type I PDZ binding motifs.
Awards and Honors
UWSOM WWAMI Curriculum
UW Freshman Collegium Seminar
Kyung Soon Lee, MD
Edelmar Navaluna, BS
1. Harris DA, Park JM, Soon-Lee K, Xu C, Stella N, Hague C (2017) Label-free dynamic mass redistribution reveals low density, pro-survival .1B –adrenergic receptors in human SW480 colon carcinoma cells. J Pharmacol Exp Ther 361(2): 219-228.
2. Kountz TS, Lee KS, Aggarwal-Howarth S, Curran E, Park JM, Harris DA, Stewart A, Hendrickson J, Camp ND, Wolf-Yadlin A, Wang EH, Scott JD, Hague C (2016) Endogenous N-terminal domain cleavage modulates .1D-adrenergic receptor pharmacodynamics. J Biol Chem 291: 18210-18221.
3. Camp ND, Lee KS, Cherry A, Wacker-Mhyre JL, Kountz TS, Park JM, Harris DA, Estrada M, Stewart A, Stella N, Wolf-Yadlin A, Hague C (2016) Dynamic mass redistribution reveals diverging importance of PDZ-ligands for G protein-coupled receptor pharmacodynamics. Pharmacol. Res. 105: 13-21. (doi:10.1016).
4. Camp ND, Lee KS, Wacker-Mhyre J, Kountz TS, Park JM, Harris DA, Estrada ME, Stewart A, Wolf-Yadlin A, Hague C (2015) Individual protomers of a G-protein coupled receptor dimer integrate distinct functional modules. Cell Disc (http://www.nature.com/articles/celldisc201511 )
5. Lyssand JS, Lee KS, DeFino M, Adams ME, Hague C. (2011) Syntrophin isoforms play specific functional roles in the 1D-AR/DAPC signalosome. Biochem. Biophys. Res. Commun. 412(4): 596-601.