Fields of Research
- Molecular Basis of Disease
- Intracellular Signaling
- Drug Discovery and Precision Medicine
Deploying human stem cell models to investigate mechanisms of neurodevelopment and disease.
We are using cutting edge techniques in human induced pluripotent stem cell (iPSCs) technology, genome editing and human stem cell models derived from autism patients, to study how aberrant signaling pathways contribute to neuropathology of autism.
Awards and Honors
Ferreccio A, et al. 2018. Inducible CRISPR genome editing platform in naive human embryonic stem cells. Cell Cycle. 2018;17(5):535-549.
Sperber H, Mathieu J, Wang Y, Ferreccio A, et al. 2015. The metabolic enzyme, nicotinamide N-methyltransferase regulates the epigenetic landscape during naïve to primed human embryonic stem cell transition. Nature Cell Biology. 2015 Dec;17(12):1523-35.
Mathieu J, Zhou W, Xing Y, Sperber H, Ferreccio A, Agoston Z, Kuppusamy K, Moon RT, Ruohola-Baker H. Hypoxia-inducible factors have distinct and stage-specific roles during reprogramming of human cells to pluripotency. Cell Stem Cell. 2014 May 1;14(5):592-605.