Profile
Contact Information
Why Pharmacology?
Publications
Amanda Bradley Profile

Fields of Research

  • Cell Signaling & Cell/Environment Interactions
  • Gene Expression, Cell Cycle & Chromosome Biolog

Research Summary

Studying the role sumoylation plays in protein modification during environmental stress.


Research Statement

Cells can sense and adapt to different environmental stress conditions. The inability to adapt to rapidly changing environments may result in cellular death. I am interested in how the post-translational protein modification SUMO aids in this process.


Awards and Honors

HHMI Gilliam Fellowship

NSF Honorable Mention

Acheivement Rewards for College Scientists (ARCS)


Awards and Honors

HHMI Gilliam Fellowship

NSF Honorable Mention

Acheivement Rewards for College Scientists (ARCS)

Amanda Bradley

Graduate Student

Affiliations

MCB Program

Explore more on social profiles

Why Pharmacology?

I chose a career in Pharmacology because I want to understand the microcellular processes that affect health, in order to discover medicines that alleviate suffering from disease.

Amanda Bradley

Graduate Student

Affiliations

MCB Program

Explore more on social profiles

Contact Information

Faculty

Building:
HSB
Room:
E-410
Box:
357280
Phone:
206-616-1967

Lab

Building:
HSB
Room:
E-410
Box:
357280
Phone:
206-616-1967
Web Link:
https://gardnerlab.org/

Amanda Bradley

Graduate Student

Affiliations

MCB Program

Explore more on social profiles

Courses

Amanda Bradley

Graduate Student

Affiliations

MCB Program

Explore more on social profiles

Students/Postdocs

Amanda Bradley

Graduate Student

Affiliations

MCB Program

Explore more on social profiles

Publications

Select Publications

Publications

Dynamic Sumoylation of a Conserved Transcription Corepressor Prevents Persistent Inclusion Formation during Hyperosmotic Stress.

Oeser ML, Amen T, Nadel CM, Bradley AI, Reed BJ, Jones RD, Gopalan J, Kaganovich D, Gardner RG.

PLoS Genet. 2016 Jan 22;12(1):e1005809. doi: 10.1371/journal.pgen.1005809. eCollection 2016 Jan.

PMID: 26800527.

Single-cell genetic analysis reveals insights into clonal development of prostate cancers and indicates loss of PTEN as a marker of poor prognosis.

Heselmeyer-Haddad KM, Berroa Garcia LY, Bradley A, Hernandez L, Hu Y, Habermann JK, Dumke C, Thorns C, Perner S, Pestova E, Burke C, Chowdhury SA, Schwartz R, Schäffer AA, Paris PL, Ried T.

Am J Pathol. 2014 Oct;184(10):2671-86. doi: 10.1016/j.ajpath.2014.06.030. Epub 2014 Aug 14.

PMID: 25131421

Single-cell genetic analysis of ductal carcinoma in situ and invasive breast cancer reveals enormous tumor heterogeneity yet conserved genomic imbalances and gain of MYC during progression.

Heselmeyer-Haddad K, Berroa Garcia LY, Bradley A, Ortiz-Melendez C, Lee WJ, Christensen R, Prindiville SA, Calzone KA, Soballe PW, Hu Y, Chowdhury SA, Schwartz R, Schäffer AA, Ried T.

Am J Pathol. 2012 Nov;181(5):1807-22. doi: 10.1016/j.ajpath.2012.07.012. Epub 2012 Oct 8.

PMID: 23062488

Amanda Bradley

Graduate Student

Affiliations

MCB Program

Explore more on social profiles